Adiponectin levels in patients with atherosclerotic cerebral infarction and polymorphic analysis of related gene SNP + 45 T/G in the island area of East Zhejiang
- Author:
- No author available
- Journal Title:
- Chinese Journal of Nautical Medicine and Hyperbaric Medicine
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1009-6906.2013.05.007.1
- Key Word:
- 脂联素;基因多态性;脑梗死;Adiponectin;Gene polymorphism;Cerebral infarction
Abstract： Objective To investigate the levels of plasma adiponectin in patients with atherosclerotic cerebral infarction and related gene SNP + 45 polymorphism and the correlation between them in island area of East Zhejiang.Methods The levels of plasma adiponectin were measured with ELISA,and related gene SNP +45 polyrnorphism was monitored with polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP).Results The frequencies of TG + GG genotype and G allele in the cerebral infarction (CI) group were all significantly higher than those in the control group,while the levels of plasma adiponectin in the CI group were lower than those in control group.Logistic regression analysis revealed that the adiponectin gene SNP + 45 TG + GG was positively correlated with that of CI patients,and the levels of plasma adiponectin were negatively associated with CI patients.Conclusions Adiponectin gene TG + GG genotype was possibly a susceptible genotype associated with those patients with atherosclerotic cerebral infarction in island area of East Zhejiang.The occurrence of CI might be resulted from its effect on the expression of plasma adiponectin.
- [1]辛雅萍,张苏河,李青菊,等.脂联素SNP45与2型糖尿病合并脑梗死相关性研究[J].2009,(22).
- [2]周南南,卓晶明,王建春,等.脂联素基因+45T/G单核苷酸多态性与汉族男性早发冠心病的相关性[J].2011,(48).
- [3]Zhang M,Rong YY,Zhang Y,etc.Local adiponectin treatment reduces atherosclerotic plaque size in rabbits.[J].2007,193(1).
- [4]Botella Carretero JI,Luque Ramirez M,Sanchon R,etc.Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study.[J].2006,21(9).
- [5]Yamaguchi K,Kawahara K,Ishiwaki A,etc.Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males.[J].2010,56(2).
- [6]Kang ES,Park SY,Kim HJ,etc.The influence of adiponectin gene polymorphism on the rosiglitazone response in patients with type 2 diabetes.[J].2005,28(5).
- [7]Ouchi N,Ohashi K,Rakugi H,etc.Hypoadiponectinemia is an independent risk factor for hypertension.[J].2004,43(6).
- [8]Sentinelli F,Verrienti A,Filippi E,etc.The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age <or=50 years).[J].2005,83(9).
- [9]Yamauchi T,Kadowaki T.Adiponectin and adiponectin receptors.[J].2005,26(3).
- [10]Przemys?aw, Krasnod?bski,Grzegorz, Opolski,Waldemar, Karnafel.Plasma adiponectin levels in acute myocardial infarction and during the postinfarction recovery period in patients with type 2 diabetes mellitus.[J].2011,69(9).
- [11]Ema, Kantorova,Maria, Chomova,Egon, Kurca,etc.Leptin, adiponectin and ghrelin, new potential mediators of ischemic stroke.[J].2011,32(5).
- [12]R. Jothimalar,Jnankumar Choudhury,Devadrita Biswas,etc.Adiponectin Gene Polymorphism and its Association with Type 2 Diabetes Mellitus[J].2011,26(2).
- [13]Chae JS,Lee JH,Kim OY,etc.Association of the 276G->T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans.[J].2005,82(4).
- [14]Scholmerich J,Schmitz G,Schaffler A,etc.Gly15Gly polymorphism within the human adipocyte-specific apM-1gene but not Tyr111His polymorphism is associated with higher levels of cholesterol and LDL-cholesterol in caucasian patients with type 2 diabetes.[J].2001,109(6).
- [15]杨秀娟,许宏伟,袁宁,等.湖南汉族人群脂联素基因多态性分布及其与动脉粥样硬化性脑梗死和相关危险因素的关系[J].2008,(11).