Abstract: Objective To study the effect of micro-found drilling cranium and hyperbaric oxygen (HBO)on cerebral hemorrhage.Methods A total of 455 cases of cerebral hemorrhage were divided into two groups.HBO group(297 cases)were treated with HBO after micro-found drilling cranium and the control group(158 cases)were single with micro-found drilling cranium.Therapeutic effects,activity of daily living and the changes of cerebral vascular function determination before and after treatment were observed in each group.Results The effective rate,excellence rate,the independently completing daily live rate and cerebral vascular function in HBO group were significantly higher than those in control group(P<0.05).There lied obviously differences in cerebral vascular function determination between before and after HBO therapy(P<0.01).Conclusions The treatment of HBO after micro-found drilling cranium on cerebral hemorrhage can significantly increase the cure rate,decrease mutilation rate,and enhance the patients'survival and living quality.Cerebral vascular function determination may give some clues to prognosis and therapy.