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Influence of "prevent-sick syrup" on plasma vasopressin and serum gastrin level in testees with hypersusceptibility to sea sickness
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-6906.2005.04.007
- Key Word:
- 防晕船口服液;晕船;血管加压素;胃泌素
Abstract： 目的观察防晕船口服液在海上预防晕船时对晕船高敏者血浆血管加压素和血清胃泌素水平的影响.方法在登陆艇上进行双盲对照试验,40名晕船高敏者分为2组,分别于开船前30 min服用安慰剂(对照组)和防晕船口服液(试验组),用放射免疫法测定航渡前后受试者血浆血管加压素和血清胃泌素水平,记录受试者出现的晕船症状并评分.结果试验组晕船症状评分和对照组相比显著降低(4.80±0.69分υs 7.12±0.28分,P＜0.01),恶心呕吐症状评分降低更为明显(1.45±0.46分υs 3.70±0.42分,P＜0.01).航渡前两组受试者血浆血管加压素(24.06±2.29 υs 24.54±1.76 ng/L)和血清胃泌素(51.80±8.32 υs 50.36±8.14 ng/L)水平差别无统计学意义(P＞0.05);航渡后试验组血浆血管加压素(29.55±2.40 ng/L)明显低于对照组(37.98±2.86 ng/L),血清胃泌素(73.11±12.10 ng/L)水平显著高于对照组(40.38±5.99 ng/L).在对照组,航渡后血浆血管加压素水平显著升高,血清胃泌素则有所降低,但无统计学意义(P＞0.05).在试验组,航渡后血浆血管加压素和血清胃泌素水平较航渡前均有所升高,但无统计学意义(P＞0.05).结论防晕船口服液具有明显的预防晕船作用,其抗运动病机制可能与降低血浆血管加压素水平和提高血清胃泌素水平有关.
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