You Position: Home > Paper

Effects of hyperbaric oxygen on neuron specific enolase after cerebral ischemia/reperfusion in rats

( views:0, downloads:0 )
Author:
No author available
Journal Title:
CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
Issue:
4
DOI:
10.3760/cma.j.issn.1009-6906.2004.04.005
Key Word:
高压氧;脑缺血再灌注;神经元特异性烯醇化酶

Abstract´╝Ü 目的研究高压氧(HBO) 对大鼠局灶性脑缺血再灌注(IR)时,大鼠脑梗塞体积,脑组织病理改变及神经元特异性烯醇化酶(NSE)含量的影响.方法用线栓法制备阻断大脑中动脉(MCA)的局灶性脑IR模型.Wistar大鼠30只,随机分为5组:正常对照组(N组,n=6),缺血再灌注2 h+常压空气组(R1组,n=6),缺血再灌注24h+常压空气组(R2组,n=6),缺血再灌注2 h+HBO组(H1组,n=6),缺血再灌注24h+HBO组(H2组,n=6).R1、R2、H1、H2组缺血时间均为2 h.R1、R2组暴露于常压空气,H1、H2组暴露于2.5 MPa氧气.病理切片用HE染色,用Swanson方法测定脑梗塞体积,用酶联免疫法测定NSE含量.结果 H1、H2组与R1、R2组相比,神经元缺血性损害较轻,脑梗塞体积缩小,NSE含量明显下降,差异有统计学意义.结论 HBO能减轻缺血性脑损害,保护脑组织.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn