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MR报告基因成像研究现状

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Author:: No author available

Journal Title:: Chinese Journal of Radiology

Issue:: 2

DOI:: 10.3760/cma.j.issn.1005-1201.2014.02.026

Key Word:: No keyword available

Abstract：近年来,影像报告基因的应用极大促进了活体生物学过程的非侵入监测成像,这些基因编码的产物具有荧光,能结合放射性标记物并改变MR信号,结合相应的显像技术可用于示踪细胞如干细胞迁移存活状况、监测目的基因如治疗基因表达情况、检测感兴趣因子如启动子的活性等…,这种成像方法称为报告基因成像.与其他成像方法相比,MRI具有很高的分辨率,能同时获得解剖和生理信息,有利于进行活体研究,因此吸引了越来越多研究者的关注.

Reference

[1]元建鹏,梁碧玲,钟镜联,等.MR评价酪氨酸酶基因在人胚胎肾293细胞表达的实验研究[J].2004,(6).
[2]张龙江,宋光义,包颜明.分子影像学的研究和进展[J].2002,(10).
[3]Xu H,Goins WF,Ahrens ET,etc.A new transgene reporter for in vivo magnetic resonance imaging.[J].2005,11(4).
[4]Benveniste H,Weissleder R,Chiocca EA,etc.In vivo magnetic resonance imaging of transgene expression.[J].2000,6(3).
[5]Zhou R,Wilson JM,Glickson JD,etc.In vivo detection of gene expression in liver by 31P nuclear magnetic resonance spectroscopy employing creatine kinase as a marker gene.[J].2001,98(9).
[6]Gossuin Y,Monseux A,Roch A,etc.Ferritin-induced relaxation in tissues: An in vitro study.[J].2004,20(4).
[7]Zurkiya O,Hu X,Chan AW.MagA is sufficient for producing magnetic nanoparticles in mammalian cells, making it an MRI reporter.[J].2008,59(6).
[8]Minton NP,Brown JM,Liu SC,etc.Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis.[J].2002,9(4).
[9]Hans Reinecke,Jennifer Deem,Anna V. Naumova,etc.Ferritin Overexpression for Noninvasive Magnetic Resonance Imaging-Based Tracking of Stem Cells Transplanted into the Heart[J].2010,9(4).
[10]Heverhagen JT,Alfke H,Czubayko F,etc.In vitro MR imaging of regulated gene expression.[J].2003,228(2).
[11]Wang K,Jin G,Li L,etc.MR reporter gene imaging of endostatin expression and therapy.[J].2010,12(5).
[12]McMahon MT,Gilad AA,Berman SM,etc.New "multicolor" polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI.[J].2008,60(4).
[13]A P, Koretsky,M J, Brosnan,L H, Chen,etc.NMR detection of creatine kinase expressed in liver of transgenic mice: determination of free ADP levels.[J].1990,87.
[14]Ahrens ET,Iordanova B.In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration.[J].2012,59(2).
[15]James P. Basilion,E. Antonio Chiocca,Anna Moore,etc.Measuring transferrin receptor gene expression by NMR imaging[J].1998,1402(3).
[16]Hamstra DA,Moffat BA,Chen M,etc.The use of (19)F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies.[J].2004,10(5).
[17]Van der Linden A,Debyser Z,Toelen J,etc.Evaluation of the specificity and sensitivity of ferritin as an MRI reporter gene in the mouse brain using lentiviral and adeno-associated viral vectors.[J].2011,18(6).
[18]Albertini A,Arosio P,Levi S,etc.Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: in vivo role of ferritin ferroxidase activity.[J].2000,275(33).
[19]Wadghiri YZ,Bernas LM,Turnbull DH,etc.Cellular MRI contrast via coexpression of transferrin receptor and ferritin.[J].2006,56(1).
[20]Iordanova, B.,Robison, C.S.,Ahrens, E.T..Design and characterization of a chimeric ferritin with enhanced iron loading and transverse NMR relaxation rate[J].2010,15(6).
[21]Bengtsson NE,Scott E,Brown G.lacZ as a genetic reporter for real-time MRI.[J].2010,63(3).
[22]Sweeney HL,Walter G,Barton ER.Noninvasive measurement of gene expression in skeletal muscle.[J].2000,97(10).
[23]Cohen B,Benjamin LE,Ziv K,etc.MRI detection of transcriptional regulation of gene expression in transgenic mice.[J].2007,13(4).
[24]Burgess JG,Sode K,Nakamura C,etc.An iron-regulated gene, magA, encoding an iron transport protein of Magnetospirillum sp. strain AMB-1.[J].1995,270(47).
[25]Bredow S,Enochs WS,Bogdanova A,etc.MR imaging and scintigraphy of gene expression through melanin induction.[J].1997,204(2).
[26]Benoit MR,Mayer D,Barak Y.Visualizing implanted tumors in mice with magnetic resonance imaging using magnetotactic bacteria.[J].2009,15(16).
[27]Cohen B,Dafni H,Meir G,etc.Ferritin as an endogenous MRI reporter for noninvasive imaging of gene expression in c6 glioma tumors.[J].2005,7(2).
[28]Uebe R,Henn V,Schuler D.The MagA protein of Magnetospirilla is not involved in bacterial magnetite biomineralization.[J].2012,194(5).
[29]Liu L,Mason RP,Cui W,etc.S-Gal, a novel 1H MRI reporter for beta-galactosidase.[J].2010,64(1).
[30]Hill, Philip J.,Stritzker, Jochen,Scadeng, Miriam,etc.Magnetic Resonance Imaging of Tumors Colonized with Bacterial Ferritin-Expressing Escherichia coli.[J].2011,6(10).