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肿瘤冷冻免疫及联合细胞免疫治疗的现状与进展

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Author:: No author available

Journal Title:: Chinese Journal of Radiology

Issue:: 4

DOI:: 10.3760/cma.j.issn.1005-1201.2013.04.025

Key Word:: No keyword available

Abstract：一、概述冷冻消融是目前临床广泛应用的在影像设备引导下行肿瘤局部低温灭活的治疗技术,过去曾用于开放外科术中对肿瘤进行冷冻灭活,被广泛用于治疗皮肤癌、前列腺癌、肝癌、乳腺癌、肺癌、肾癌和骨肿瘤等[1-4].在影像设备引导下行肿瘤的冷冻消融治疗与外科手术切除相比具有许多优点:经皮穿刺冷冻消融创伤较小、安全性高,疼痛耐受性好、术后恢复快及治疗费用较低,易被患者接受.冷冻免疫反应是指冷冻消融后肿瘤细胞坏死释放肿瘤抗原,刺激体内免疫系统产生抗肿瘤免疫反应,有助于机体清除转移灶或原发灶内残余肿瘤细胞[5].早期大量的基础和临床研究证明冷冻消融具有促进免疫功能的潜在优势.

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