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MR spectroscopy of prostate cancer: correlation study of metabolic characters with Gleason score
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 11
- DOI:
- 10.3760/j.issn:1005-1201.2006.11.016
- Key Word:
- 磁共振波谱学;前列腺肿瘤;病理学
Abstract： 目的 以MR波谱分析(MRS)方法定量分析前列腺癌(Pca)的代谢特征与Gleason评分的关系. 方法 经手术病理或穿刺活检证实的Pca 21例以6分区的方法(将前列腺分为左、右侧的底部、中部、尖部)进行MRS定量分析.在MRS代谢图上标记出手术病理或穿刺活检取材位置归入相应的分区,测量其(胆碱+肌酸)/枸椽酸盐(CC/C)的比值.将Pca的MRS代谢结果与其Gleason评分进行对照. 结果 21例患者74分区有癌,其CC/C均值为2.13±0.82;52分区无癌,其CC/C均值为0.59±0.20.二者间的差异有统计学意义(t=7.72,P=0.00).Pca的CC/C比值与Gleason评分相关(r=0.66,P=0.01).Gleason评分≥7组和＜7组的CC/C比值分别为2.61±0.79和1.69±0.59,差异有统计学意义(t=3.06,P=0.01). 结论 CC/C与Gleason评分有相关性,MRS有可能无创地评价Pca的病理分级.
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