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Esophageal intraluminal irradiation stent :primary results of development and clinical application
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 9
- DOI:
- 10.3760/j.issn:1005-1201.2004.09.005
- Key Word:
- 食管肿瘤;碘放射性同位素;支架;近距离放射疗法;放射学,介入性
Abstract： 目的探索食管内照射支架研制、临床使用的可行性、安全性及初步疗效.方法选择合适的覆膜或裸食管支架,于支架外周按一定的规律固定上特制的可容纳放射粒子的鞘,根据患者病变的范围通过治疗计划系统(treatment plan system,TPS)计算出放射粒子的剂量,将放射粒子装进上述鞘内即制成食管内照射支架.临床选择15例食管癌患者,临床分级为Ⅱ～Ⅳ级,将放疗支架植入到患者病变食管内并进行临床随访.结果 15例患者内照射支架均释放到位,释放过程顺利,释放过程中未出现放射粒子脱落现象;全身γ射线显像(ECT)复查未发现非靶器官显像;患者全身一般状况明显好转,血象和免疫指标亦未见明显变化,未出现如食管穿孔、出血等并发症;13例术后1个月CT复查提示病灶的厚度较术前变簿, 2例变大,3例随访近8个月,CT复查病变厚度较术前明显变薄,胃镜检查并活检提示支架捆绑粒子部位肿瘤明显缩小,活检未发现肿瘤细胞生长.结论食管内照射支架临床使用是安全、可行、有效的,其临床长期疗效需进一步随访观察及对照研究.
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