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CT pulmonary angiograghy in the diagnosis of pulmonary embolism:a Meta analysis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 7
- DOI:
- 10.3760/j.issn:1005-1201.2004.07.008
- Key Word:
- 肺栓塞;体层摄影术,X线计算机;Meta分析
Abstract： 目的对以肺动脉造影为金标准,研究CT肺动脉造影(CTPA)诊断肺动脉栓塞(PE)的文献进行Meta汇总分析,评价CTPA对PE的临床诊断价值.方法检索Cochrane图书馆、PubMed,OVID数据库和中国期刊网中的英文和中文文献,按照Cochrane协作网推荐的诊断试验的纳入标准筛选文献,并对纳入文献进行质量评估,提取纳入研究的特征信息.数据分析采用Meta-Testversion 0.9软件,检验异质性,并根据异质性结果选择相应的效应模型.对所有研究予以加权定量合并,计算灵敏度和特异度及其95%可信区间.绘制汇总受试者工作特征曲线(SROC),并计算曲线下面积.最后进行敏感性分析.结果共纳入10篇英文文献,其中7篇为A级,3篇为B级.研究对象共计855人,CTPA诊断PE的灵敏度的范围是0.57～1.00,特异度的范围是0.78～1.00.纳入研究存在异质性.按照随机效应模型计算汇总灵敏度和特异度及95%可信区间分别为0.84(0.73,0.91)和0.91(0.87,0.94).SROC曲线下面积为94.95%.纳入文献稳定性好.结论汇总目前关于CTPA诊断PE的研究显示,CTPA是一种灵敏度和特异度较高的无创性检查方法,还需要高质量的前瞻性研究以更准确地评价其临床价值.
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