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HPV E6/E7 mRNA检测在子宫颈病变筛查中应用的初步探讨
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Obstetrics and Gynecology
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.0529-567x.2019.12.010
- Key Word:
- No keyword available
Abstract： 目的 探讨HPV E6/E7 mRNA检测在子宫颈病变筛查中的应用.方法 收集2017年1月—2018年5月在山东大学附属省立医院经病理检查确诊为子宫颈上皮内瘤变(CIN)Ⅱ及以上病变(CINⅡ+)的1 256例患者的临床资料,比较CINⅡ+患者在病理检查确诊前1年内液基薄层细胞学检查(TCT)、高危型HPV(HR?HPV)DNA及HPV E6/E7 mRNA检测的结果.结果 TCT、HR?HPV DNA及HPV E6/E7 mRNA检测的漏检率分别为11.90%(135/1 134)、3.23%(25/773)、0.89%(3/336),HPV E6/E7 mRNA检测的漏检率明显低于TCT和HR?HPV DNA检测(P<0.05).HPV E6/E7 mRNA+TCT的漏检率为0(0/296),与单独HPV E6/E7 mRNA检测相比,差异无统计学意义(P>0.05).结论 HPV E6/E7 mRNA检测在子宫颈病变筛查中的漏检率明显低于TCT检查及HR?HPV DNA检测,且HPV E6/E7 mRNA+TCT与单独HPV E6/E7 mRNA检测比较无显著差异,提示,HPV E6/E7 mRNA检测可作为子宫颈病变筛查方法的选择.
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