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Chromosome abnormality rate and related factors of spontaneous abortion in early pregnancy

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Author:
No author available
Journal Title:
Chinese Journal of Obstetrics and Gynecology
Issue:
12
DOI:
10.3760/cma.j.issn.0529-567x.2019.12.002
Key Word:
流产;自然;染色体畸变;妊娠初期;高通量核苷酸序列分析;体外受精;胚胎移植;Abortion;spontaneous;Chromosome aberrations;Pregnancy trimester;first;High-throughput nucleotide sequencing;Fertilization in vitro;Embryo transfer

Abstract: Objective To investigate chromosome abnormality rate and related factors of spontaneous abortion in early pregnancy. Methods A total of 831 tissue samples of spontaneous abortion in early pregnancy were collected from June 2015 to August 2018 in the First Affiliated Hospital of Nanjing Medical University. Chromosomal copy number was analyzed by next generation sequencing (NGS). The relationships between chromosome abnormality and maternal age, in vitro fertilization?embryo transfer (IVF?ET) pregnancy, number of previous spontaneous abortions, history of live birth were analyzed by statistical methods. Results Among 831 tissue samples of spontaneous abortion in early pregnancy, 461 (55.5%, 461/831) were found to have chromosome abnormalities. Maternal age (OR=1.107, 95%CI: 1.070-1.145) and history of live birth ( OR=1.909, 95%CI : 1.182-3.083) were the positive correlative factors of chromosome abnormality. Times of previous spontaneous abortion (OR=0.807, 95%CI: 0.702-0.928) and IVF?ET pregnancy ( OR=0.554, 95%CI : 0.404-0.760) were the negative correlative factors of chromosome abnormality. Conclusions Chromosome abnormality is an important cause of spontaneous abortion in early pregnancy. The rate of chromosome abnormality increases with the increase of maternal age and the history of live birth, and decreases with the increase of number of previous spontaneous abortion and IVF?ET pregnancy.

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