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复发性流产与反复种植失败的病因和治疗新观点
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Obstetrics and Gynecology
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.0529-567x.2019.12.001
- Key Word:
- No keyword available
Abstract： 复发性流产(RSA)的病因复杂,而且至少仍有50%的RSA患者病因至今未明,属于原因不明RSA(URSA).近些年,经历过辅助生殖技术治疗的患者中,也存在特殊类型的流产,即反复种植失败(RIF).RSA和RIF可同时发生,其发病机制存在共同点,约50%的患者病因未明,多认为与免疫和遗传因素有关;免疫因素分为同种免疫型和自身免疫型,遗传上与尚未确定的致病基因有关.URSA和RIF治疗的新进展包括抗凝疗法(低分子肝素和阿司匹林抗凝)、免疫抑制(糖皮质激素、免疫球蛋白注射、免疫抑制剂)、免疫调节(肿瘤坏死因子α拮抗剂、粒细胞集落刺激因子注射、宫腔内注射外周血单核细胞)、体外受精-胚胎移植和基因筛查等.
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