Paper - WANFANG MED ONLINE

You Position: Home > Paper

sFlt-1基因的表达调控及作为子痫前期治疗靶点的研究进展

( views:75, downloads:577 )

Author:: No author available

Journal Title:: Chinese Journal of Obstetrics and Gynecology

Issue:: 4

DOI:: 10.3760/cma.j.issn.0529-567x.2019.04.012

Key Word:: No keyword available

Abstract：子痫前期是妊娠期特发性疾病,发生率为2%～8%,是导致母儿不良妊娠结局及死亡的主要原因之一.子痫前期的发病机制尚不清楚,大量研究认为可能与胎盘功能障碍及广泛的血管内皮损伤有关.近年来,抗血管生成因子——可溶性fms样酪氨酸激酶受体1(sFlt-1)成为子痫前期的预测指标之一,越来越多的学者开始关注sFlt-1作为治疗靶点在子痫前期的早期预防和治疗中的应用价值.

Reference

[1]Onda, Kenji,Tong, Stephen,Nakahara, Anzu,etc.Sofalcone Upregulates the Nuclear Factor (Erythroid-Derived 2)-Like 2/Heme Oxygenase-1 Pathway, Reduces Soluble fms-Like Tyrosine Kinase-1, and Quenches Endothelial Dysfunction Potential Therapeutic for Preeclampsia[J].2015,65(4).
[2]D, Berg,F, Thaler,E, Kuss.Concentrations of 2-hydroxyoestrogens in human sera measured by a heterologous immunoassay with an 125I-labelled ligand.[J].1982,100(1).
[3]Hacı Kemal Erdemli,Pınar Yıldırımlar,Tayfun Yaşar Alper,etc.Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia[J].2014,33(4).
[4]Nakada E,Walley KR,Nakada T.Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells.[J].2009,30(9).
[5]Cissy Chenyi, Zhou,Shakil, Ahmad,TieJuan, Mi,etc.Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy.[J].2007,100.
[6]Ma, Su-ling,Tian, Xiao-yu,Wang, Ya-qi,etc.Vitamin D Supplementation Prevents Placental Ischemia Induced Endothelial Dysfunction by Downregulating Placental Soluble FMS-Like Tyrosine Kinase-1[J].2017,36(12).
[7]L, Miquerol,B L, Langille,A, Nagy.Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression.[J].2000,127(18).
[8]Thomas CP,Andrews JI,Raikwar NS.A recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia.[J].2009,94(7).
[9]Shakil, Ahmad,Asif, Ahmed.Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia.[J].2004,95.
[10]Bei Xu,Renuka Shanmugalingam,Katrina Chau,etc.The effect of acetyl salicylic acid (Aspirin) on trophoblast-endothelial interaction in vitro[J].2017,124.
[11]Rana,S.,Rajakumar,A.,Geahchan,C.,etc.Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway[J].2014,28(10).
[12]Natalie J, Hannan,Fiona C, Brownfoot,Ping, Cannon,etc.Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment.[J].2017,7(1).
[13]Saito S,Ochiai A,Ito TK,etc.Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells.[J].2009,113(10).
[14]Brownfoot, Fiona C.,Illanes, Sebastian E.,Cannon, Ping,etc.Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction[J].2016,214(3).
[15]Costantine,M.M.,Cleary,K..Pravastatin for the prevention of preeclampsia in high-risk pregnant women[J].2013,121(2 Pt.1).
[16]Lee, D. K.,Nevo, O..2-Methoxyestradiol regulates VEGFR-2 and sFlt-1 expression in human placenta[J].2015,36(2).
[17]Jebbink J,Afink G,Ris Stalpers C,etc.Expression of Placental FLT1 Transcript Variants Relates to Both Gestational Hypertensive Disease and Fetal Growth.[J].2011,58(1).
[18]Colby A, Souders,Sharon E, Maynard,Jing, Yan,etc.Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia.[J].2015,16(6).
[19]Whitehead CL,Palmer KR,Nilsson U,etc.Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia.[J].2011,118(10).
[20]Kirsten R. Palmer,Tu’uhevaha J. Kaitu’u-Lino,Ping Cannon,etc.Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia[J].2016,(6).
[21]Tamayo E,Lu F,Bytautiene E,etc.Using pravastatin to improve the vascular reactivity in a mouse model of soluble fms-like tyrosine kinase-1-induced preeclampsia.[J].2010,116(1).
[22]Melissa, Cudmore,Shakil, Ahmad,Bahjat, Al-Ani,etc.Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1.[J].2007,115.
[23]Li, C.,Raikwar, N. S.,Santillan, M. K.,etc.Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1[J].2015,36(4).
[24]Kenji, Onda,Stephen, Tong,Sally, Beard,etc.Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction.[J].2017,69(3).
[25]Murakami M,Ohkuchi A,Sato Y,etc.Effect of recombinant placental growth factor 2 on hypertension induced by full-length mouse soluble fms-like tyrosine kinase 1 adenoviral vector in pregnant mice.[J].2009,54(5).
[26]Brownfoot, Fiona C.,Tong, Stephen,Hannan, Natalie J.,etc.Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia[J].2015,66(3).
[27]Astrid Bergmann,Shakil Ahmad,Melissa Cudmore,etc.Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model[J].2010,14(6b).
[28]Ye, Louie,Gratton, Amy,Hannan, Natalie J.,etc.Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta[J].2016,48.
[29]Kirsten R. Palmer,Stephen Tong,Laura Tuohey.Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production[J].2016,94(3).
[30]Thadhani R,Kisner T,Hagmann H,etc.Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia.[J].2011,124(8).
[31]Brownfoot, Fiona C.,Tong, Stephen,Hannan, Natalie J.,etc.YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia[J].2015,413(Issue C).
[32]Zhong H,Simons JW,Giannakakou P,etc.2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.[J].2003,3(4).
[33]Li Z,Zhang Y,Ying-Ma J,etc.Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia.[J].2007,50(4).
[34]Cockrell K,Arany M,Stec DE,etc.Induction of heme oxygenase-1 attenuates sFlt-1-induced hypertension in pregnant rats.[J].2011,301(5Part.2).
[35]Tong, Stephen,Kaitu'u-Lino, Tu'uhevaha J.,Onda, Kenji,etc.Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion[J].2015,66(5).
[36]Karalis, Dean G.,Hill, Alethea N.,Clifton, Shari,etc.The risks of statin use in pregnancy: A systematic review[J].2016,10(5).
[37]A, Ahmed,M, Rahman,X, Zhang,etc.Induction of placental heme oxygenase-1 is protective against TNFalpha-induced cytotoxicity and promotes vessel relaxation.[J].2000,6(5).
[38]Thadhani, Ravi,Hagmann, Henning,Schaarschmidt, Wiebke,etc.Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia[J].2016,27(3).
[39]Aleksey, Kazmin,Facundo, Garcia-Bournissen,Gideon, Koren.Risks of statin use during pregnancy: a systematic review.[J].2007,29(11).
[40]Palmer, K. R.,Tong, S.,Kaitu'u-Lino, T. J..Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis[J].2017,23(1).
[41]Staff,A.C.,Benton,S.J.,VonDadelszen,P.,etc.Redefining preeclampsia using placenta-derived biomarkers[J].2013,61(5).
[42]Boeckel, Jes-Niels,Guarani, Virginia,Koyanagi, Masamichi,etc.Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1[J].2011,108(8).
[43].Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta[J].2012,206(3).
[44]Ellis StephenG,Zioncheck ThomasF,Yi JooHee,etc.A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans.[J].2002,72(1).
[45]Gysler, Stefan M.,Mulla, Melissa J.,Stuhlman, Meredith,etc.Vitamin D Reverses aPL-induced Inflammation and LMWH-induced sFlt-1 Release by Human Trophoblast[J].2015,73(3).
[46]Ping Cannon,Kirsten R Palmer,Louie Ye,etc.Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity.[J].2015,66(6).