Paper - WANFANG MED ONLINE

You Position: Home > Paper

卵巢上皮性癌MyD88表达的潜在调控机制研究进展

( views:149, downloads:296 )

Author:: No author available

Journal Title:: Chinese Journal of Obstetrics and Gynecology

Issue:: 2

DOI:: 10.3760/cma.j.issn.0529-567x.2019.02.016

Key Word:: No keyword available

Abstract：髓样分化因子88(MyD88)异常表达与大约70%卵巢上皮性癌(卵巢癌)的复发、转移、紫杉醇抵抗和免疫抑制密切相关.MyD88介导的Toll样受体4(TLR4)/核因子κB(NF-κB)信号通路活化是造成卵巢癌复发、转移和预后差的主要因素之一.然而,卵巢癌细胞异常表达MyD88的分子机制仍需进一步探究.本文就目前卵巢癌细胞MyD88表达的潜在调控机制的研究作一综述.

Reference

[1]朱熠,黄建鸣,张国楠.TLR4/MyD88信号通路介导卵巢癌紫杉醇耐药机制的研究进展[J].2011,(11).
[2]Shi-Ping Liu,Jia-xin Yang,Dong-Yan Cao,etc.Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials[J].2013,(3).
[3].LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration[J].2015,25(3).
[4]Vu N. Ngo,Ryan M. Young,Roland Schmitz,etc.Oncogenically active MYD88 mutations in human lymphoma[J].2011,470(Feb.3 TN.7332).
[5]Wang,K.,Liu,F.,Zhou,L.-Y.,etc.The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489[J].2014,114(9).
[6]Yi, Zhu,Jian-Ming, Huang,Guo-Nan, Zhang,etc.Prognostic significance of MyD88 expression by human epithelial ovarian carcinoma cells.[J].2012,10.
[7]Hong, Liu,Guonan, Zhang,Jianming, Huang,etc.Atractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-κB signaling in vitro.[J].2016.
[8]Qiuyun, Wu,Lei, Han,Weiwen, Yan,etc.miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF.[J].2016.
[9]Schmitz KM,Mayer C,Grummt I,etc.Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes.[J].2010,24(20).
[10]Bergman, Y.,Cedar, H..DNA methylation dynamics in health and disease[J].2013,20(3).
[11]Dimicoli, Sophie,Wei, Yue,Bueso-Ramos, Carlos,etc.Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes.[J].2013,8(8).
[12]Sheehy,P.,Yang,G.,Treon,S.P.,etc.MYD88 L265P somatic mutation in Waldenstr?m's macroglobulinemia[J].2012,367(9).
[13]Adrian, Bird.DNA methylation patterns and epigenetic memory.[J].2002,16(1).
[14]Michael G, Kelly,Ayesha B, Alvero,Rui, Chen,etc.TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer.[J].2006,66.
[15]Jian-Ming, Huang,Guo-Nan, Zhang,Yu, Shi,etc.Atractylenolide-I sensitizes human ovarian cancer cells to paclitaxel by blocking activation of TLR4/MyD88-dependent pathway.[J].2014,4.
[16]Toloczko, Aleksandra,Jung, Audrey Y.,Hernandez, Brenda Y.,etc.MyD88 and TLR4 Expression in Epithelial Ovarian Cancer[J].2018,93(3).
[17]Schuebeler, Dirk.Function and information content of DNA methylation[J].2015,517(Jan.15 TN.7534).
[18]Czystowska,Szajnik M,Szczepanski MJ.TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer.[J].2009,28(49).
[19]Chang, Yi Seok,Jalgaonkar, Swati P.,Middleton, Justin D.,etc.Stress-inducible gene Atf3 in the noncancer host cells contributes to chemotherapy-exacerbated breast cancer metastasis[J].2017,114(34).
[20]Xiaoliang Xu,Yin Yin,Junwei Tang,etc.Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification[J].2017,8(10).
[21]Yue Li,Junetha Syed,Hiroshi Sugiyama.RNA-DNA Triplex Formation by Long Noncoding RNAs[J].2016,23(11).