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细胞自噬与卵巢上皮性癌治疗关系的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Obstetrics and Gynecology

Issue:: 11

DOI:: 10.3760/cma.j.issn.0529-567x.2018.11.017

Key Word:: No keyword available

Abstract：卵巢上皮性癌(卵巢癌)的死亡率居妇科恶性肿瘤首位,虽然近10年来卵巢癌的手术和辅助治疗方法不断取得新的进步,但患者的5年生存率仍然徘徊在47%左右[1].其主要原因除了卵巢癌早期缺乏有效的诊断手段外,肿瘤的高复发率仍一直是困扰临床的一大难题.因此,研发新型的治疗药物显得尤为重要.细胞自噬(autophagy)作为程序性细胞死亡的1种主要方式,与卵巢癌的发生、发展乃至卵巢癌治疗均有密切的关系.尤其是作为肿瘤治疗的新方向,细胞自噬与卵巢癌的关系近年已得到越来越多的关注.一方面,细胞自噬可为肿瘤的生长提供物质和能量支持从而有利于卵巢癌细胞的增殖;另一方面,在特定环境下抑制细胞自噬也可明显抑制卵巢癌肿瘤细胞的活性.Sun等[2]研究发现,细胞自噬可以促进子宫颈癌细胞系CaSki细胞凋亡;而对于卵巢癌细胞系SKOV3细胞,细胞自噬却可通过保护其存活而最终导致SKOV3细胞对顺铂产生耐药[3].本文通过综述近年来细胞自噬与卵巢癌治疗关系的研究进展,以期为卵巢癌治疗提供新的方向.

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