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阻塞性睡眠呼吸暂停与妊娠期高血压疾病关系的研究进展
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Obstetrics and Gynecology
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.0529-567x.2017.10.014
- Key Word:
- No keyword available
Abstract： 妊娠期高血压疾病(hypertensive disorders complicating pregnancy,HDCP)是妊娠期特有的疾病,以妊娠20周后血压升高[收缩压≥140 mmHg和(或)舒张压≥90 mmHg, 1 mmHg=0.133 kPa]、蛋白尿和水肿为特征,并可伴有全身多器官损害,严重时可影响母儿健康,甚至危及生命.研究发现,HDCP与心血管疾病具有共同的危险因素,如慢性高血压、肥胖、脂肪代谢紊乱和胰岛素抵抗等[1].目前认为,高龄、孕前超重[体质指数(BMI)≥24 kg/m2]、糖代谢异常、慢性肾脏疾病的孕妇更容易发生HDCP[2].尽管HDCP一直是产科领域的研究热点,但其确切的发病机制并不十分清楚,因而限制了对于HDCP疾病本质的认识及其有效的诊断和治疗[3].2012年,中华医学会呼吸病学分会睡眠呼吸障碍学组制定了《阻塞性睡眠呼吸暂停低通气综合征诊治指南》[4],提到了阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)可能引起的病变包括妊娠期高血压或子痫前期.同年,中华医学会妇产科学分会妊娠期高血压疾病学组制定了《妊娠期高血压疾病诊治指南(2012版)》[5],又于2015年进行了修订[6],修订后的HDCP诊治指南包括疾病的分类、诊断、处理、预防、管理,然而,相关内容均未涉及OSA.近年来大量研究显示,HDCP与OSA关系十分密切,本文就两者的相关研究进展进行探讨.
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