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高级别子宫内膜间质肉瘤的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Obstetrics and Gynecology

Issue:: 4

DOI:: 10.3760/cma.j.issn.0529-567x.2017.04.016

Key Word:: No keyword available

Abstract：子宫内膜间质肉瘤(endometrial stromal sarcoma,ESS)是来源于子宫内膜间质细胞的恶性肿瘤,其发生率较低,约占所有子宫恶性肿瘤的1%,但却是第2常见的子宫肉瘤[1-2].传统上,根据核分裂数可将ESS分为低级别ESS和高级别ESS.然而,进一步研究发现,核分裂活性与ESS患者的预后无明显相关性[3].由于高级别ESS缺乏特异性分化且组织学上不同于子宫内膜癌,2003年WHO分类将ESS更改为低级别ESS和未分化子宫内膜肉瘤(undifferentiated endometrial sarcoma,UES)[或未分化子宫肉瘤(undifferentiated uterine sarcoma,UUS)]两个类型.近年来,越来越多的研究表明,UES的范围过广,包含了从形态学、遗传学、临床表现及预后有明显差异的两类肿瘤,但其命名未统一.直至2014年,第4版WHO分类根据ESS临床与病理特征并结合分子遗传学研究进展将其分为低级别ESS、高级别ESS和UUS 3个类型[1].高级别ESS的发生率低,具有独特的生物学行为,近年来作为妇科肿瘤的研究热点取得了一系列的新发现并达成共识,在2014年WHO分类中作为独立的肿瘤类型得以重新提出,现将其相关研究进展综述如下.

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