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鞘氨醇激酶1的生物学功能及其与卵巢上皮性癌关系的研究进展

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Author:: No author available

Journal Title:: 中华妇产科杂志

Issue:: 2

DOI:: 10.3760/cma.j.issn.0529-567x.2016.02.014

Key Word:: No keyword available

Abstract：细胞内鞘脂代谢平衡对维持细胞稳态至关重要。鞘氨醇激酶（sphingosine kinase，SphK）1是一种鞘氨醇代谢酶，是鞘脂代谢平衡的限速酶。近年来的研究表明，SphK1是一种致癌酶，与细胞的增殖、转化和肿瘤细胞的存活、侵袭、迁移密切相关。本文就SphK1的生物学功能及其与卵巢上皮性癌（卵巢癌）关系的研究进展进行综述。

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