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子痫前期的病理生理研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Obstetrics and Gynecology

Issue:: 12

DOI:: 10.3760/cma.j.issn.0529-567x.2015.12.015

Key Word:: No keyword available

Abstract：子痫前期是指在妊娠20周及以后新出现的高血压和蛋白尿的综合征,或无蛋白尿,但存在多系统功能障碍的疾病,如血小板计数减少、肝肾功能不全、肺水肿和脑血管意外等.子痫前期在妊娠妇女中的发病率为3％～5％,是导致孕妇和围产儿死亡的主要原因[1].子痫前期可导致胎儿生长受限(FGR)和早产,或发展为子痫,是产科的危急重症,严重威胁母儿的生命安全[1].

Reference

[1]Yamamoto T,Kojima K,Suzuki Y,etc.The biological investigation of prostacyclin in preeclamptic women seen reduced endothelial function.[J].2010,29(4).
[2]Lei, Han,Xiaojie, Liu,Hongmei, Li,etc.Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia.[J].2014,9(12).
[3]Tadesse, Serkalem,Kidane, Dawit,Guller, Seth,etc.In Vivo and In Vitro Evidence for Placental DNA Damage in Preeclampsia.[J].2014,9(1).
[4]Yuan,J.,Guo,Q.,Qureshi,A.R.,etc.Circulating vascular endothelial growth factor (VEGF) and its soluble receptor 1 (sVEGFR-1) are associated with inflammation and mortality in incident dialysis patients[J].2013,28(9).
[5]Akriti S Sahay,Vidya V Patil,Deepali P Sundrani,etc.A longitudinal study of circulating angiogenic and antiangiogenic factors and AT1-AA levels in preeclampsia[J].2014,37(8).
[6]Kim, Yeon Mee,Chaemsaithong, Piya,Romero, Roberto,etc.The frequency of acute atherosis in normal pregnancy and preterm labor, preeclampsia, small-for-gestational age, fetal death and midtrimester spontaneous abortion[J].2015,28(16).
[7]G E, Lash,B E, McLaughlin,S K, MacDonald-Goodfellow,etc.Relationship between tissue damage and heme oxygenase expression in chorionic villi of term human placenta.[J].2003,284(1).
[8]Ni,H.,Qi,A.-R.,Yang,Z.-M.,etc.Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice[J].2012,287(19).
[9]Burton GJ,Yung HW,Cindrova Davies T.Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia.[J].2009,30(Suppl.A).
[10]Hecht JL,Dammann O,Faupel Badger JM,etc.Cluster analysis of placental inflammatory proteins can distinguish preeclampsia from preterm labor and premature membrane rupture in singleton deliveries less than 28 weeks of gestation.[J].2011,66(6).
[11]Tseliou, Eleni,Reich, Heidi,de Couto, Geoffrey,etc.Cardiospheres reverse adverse remodeling in chronic rat myocardial infarction: roles of soluble endoglin and Tgf-beta signaling[J].2014,109(6).
[12]Julie Vanacker,Aiswarya Viswanath,Pauline De Berdt,etc.Hypoxia Modulates the Differentiation Potential of Stem Cells of the Apical Papilla[J].2014,40(9).
[13]Purwosunu Y,Wibowo N,Rizzo N,etc.Gene expression in chorionic villous samples at 11 weeks' gestation from women destined to develop preeclampsia.[J].2008,28(10).
[14]Moffett A,Hiby SE.How Does the maternal immune system contribute to the development of pre-eclampsia?[J].2007,28(Suppl.A).
[15]Reshef Tal.The role of hypoxia and hypoxia-inducible factor-1Alpha in preeclampsia pathogenesis.[J].2012,87(6).
[16]Kobayashi, Yusuke,Yamamoto, Tatsuo,Chishima, Fumihisa,etc.Autoantibodies Isolated from Patients with Preeclampsia Induce Soluble Endoglin Production from Trophoblast Cells Via Interactions with Angiotensin II Type 1 Receptor[J].2015,73(4).
[17]Baijnath, Sooraj,Soobryan, Nerolen,Mackraj, Irene,etc.The optimization of a chronic nitric oxide synthase (NOS) inhibition model of pre-eclampsia by evaluating physiological changes[J].2014,182.
[18]Julio, Mateus,Egle, Bytautiene,Fangxian, Lu,etc.Endothelial growth factor therapy improves preeclampsia-like manifestations in a murine model induced by overexpression of sVEGFR-1.[J].2011,301(5).
[19]Salahuddin S,Young B,Levine RJ,etc.The use of angiogenic biomarkers to differentiate non-HELLP related thrombocytopenia from HELLP syndrome.[J].2010,23(5).
[20]Austgulen R,Mundal SB,Eide IP,etc.Increased endoplasmic reticulum stress in decidual tissue from pregnancies complicated by fetal growth restriction with and without pre-eclampsia.[J].2011,32(11).
[21]Lamarca,B.,Herse,F..Angiotensin II Type 1 Receptor Autoantibody (AT1-AA)-Mediated Pregnancy Hypertension[J].2013,69(4).
[22]Lyall,F.,Robson,S.C.,Bulmer,J.N..Spiral artery remodeling and trophoblast invasion in preeclampsia and fetal growth restriction relationship to clinical outcome[J].2013,62(6).
[23]Gu Y,Lewis DF,Canzoneri BJ,etc.Maternal levels of prostacyclin, thromboxane, ICAM, and VCAM in normal and preeclamptic pregnancies.[J].2010,64(6).
[24]Kalish FS,Zhao H,Wong RJ.Effect of heme oxygenase-1 deficiency on placental development.[J].2009,30(10).
[25]Blacher S,Foidart JM,Lorquet S,etc.Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast.[J].2008,23(6).
[26]Kalay,S.,Tosun,O.,Oygur,N.,etc.The role of VEGF and its soluble receptor VEGFR-1 in preterm newborns of preeclamptic mothers with RDS[J].2013,26(10).
[27]Xia Y,Ramin SM,Irani RA,etc.Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice.[J].2008,14(8).
[28]Shaker OG,Shehata H.Early prediction of preeclampsia in high-risk women.[J].2011,20(4).
[29]Huang,Q.T.,Zhang,M.,Zhong,M.,etc.Advanced glycation end products as an upstream molecule triggers ROS-induced sFlt-1 production in extravillous trophoblasts: A novel bridge between oxidative stress and preeclampsia[J].2013,34(12).
[30]Liu,W.,Wang,S.-J.,Lin,Q.-D..Study on the expressions of PHD and HIF in placentas from normal pregnant women and patients with preeclampsia[J].2014,10(3).
[31]George EM,Cockrell K,Stec DE,etc.Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertension.[J].2011,57(5).
[32].Pre-eclampsia part 1: Current understanding of its pathophysiology[J].2014,10(8).
[33]Moyes AJ,Gray GA,Maldonado Perez D,etc.Enhanced angiogenic capacity of human umbilical vein endothelial cells from women with preeclampsia.[J].2011,18(4).
[34]Pushpinder Dhillion,1 Kedra Wallace,1 Florian Herse,etc.IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy[J].2012,303(2 Pt.2).
[35]Mammoto T,Libermann TA,Hanai J,etc.Soluble endoglin contributes to the pathogenesis of preeclampsia.[J].2006,12(6).
[36]Stillman IE,Epstein FH,Sellke FW,etc.Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.[J].2003,111(5).
[37]Mistry, H. D.,Gill, C. A.,Kurlak, L. O.,etc.Association between maternal micronutrient status, oxidative stress, and common genetic variants in antioxidant enzymes at 15 weeks׳ gestation in nulliparous women who subsequently develop preeclampsia[J].2015,78(1).
[38]Ferrara N,Quaggin SE,Gerber HP,etc.Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases.[J].2003,111(5).
[39]Tereza, Cindrova-Davies,Olivera, Spasic-Boskovic,Eric, Jauniaux,etc.Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitam[J].2007,170(5).
[40].A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model.[J].2012,72(1).
[41]Leila, Rezanejhad,Jaleh, Zolghadri,Behrouz, Gharesi-Fard.Importance of anti-GRP78 antibody in pre-eclampsia.[J].2013,10(4).
[42]Wallace, Alison E.,Whitley, Guy S.,Thilaganathan, Baskaran,etc.Decidual natural killer cell receptor expression is altered in pregnancies with impaired vascular remodeling and a higher risk of pre-eclampsia[J].2015,97(1).
[43]Verlohren S,Geusens N,Morton J,etc.Inhibition of trophoblast-induced spiral artery remodeling reduces placental perfusion in rat pregnancy.[J].2010,56(2).
[44]Yung,H.-W.,Olovsson,M.,Burton,G.J.,etc.Endothelin-1 induces endoplasmic reticulum stress by activating the PLC-IP 3 pathway: Implications for placental pathophysiology in preeclampsia[J].2012,180(6).
[45]Volkov A,Tal R,Polak Charcon S,etc.Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction.[J].2010,177(6).
[46]Ventura, Walter,De Paco Matallana, Catalina,Teresa Prieto-Sanchez, Maria,etc.Uterine and umbilical artery Doppler at 28 weeks for predicting adverse pregnancy outcomes in women with abnormal uterine artery Doppler findings in the early second trimester[J].2015,35(3).
[47].Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia[J].2013,208(4).