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甘露糖结合凝集素与阴道炎症关系的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Obstetrics and Gynecology

Issue:: 11

DOI:: 10.3760/cma.j.issn.0529-567x.2015.11.016

Key Word:: No keyword available

Abstract：凝集素(lectin)是含有能识别病原碳水化合物结构域的一类蛋白质.甘露糖结合凝集素(mannose-binding lectin 或mannan-binding lectin,MBL)属C型胶原样凝集素,与感染性疾病、自身免疫系统疾病等全身各系统疾病有广泛的联系.MBL可与病原体表面的甘露糖等糖基结合而发挥作用,是天然免疫系统的重要免疫因子,也是抵御病原微生物的第一道防线,有"广义抗体"之称[1].已有研究证实,以MBL为代表的天然免疫因子与阴道炎症的发生、发展及预后有相关性.

Reference

[1]金振晓,胡军,胡巧侠,等.人甘露糖结合凝集素（MBL）的纯化与兔抗人MBL抗血清的制备[J].2001,(6).
[2]迟来婷,曲利军.甘露糖结合凝集素在感染性疾病中的研究进展[J].2013,(5).
[3]张瑜,彭景,张怡.甘露糖结合凝集素基因多态性与复发性细菌性阴道病易感性关系的研究[J].2010,(10).
[4]贾天军,李萍,张庶民,等.蒙古族人MBL基因exon I 54位密码子点突变频率与其血浆含量的相关性[J].2004,(3).
[5]牛战琴,郑海雅,石一复.甘露糖结合受体在阴道上皮细胞抗念珠菌中的作用[J].2008,(5).
[6]金振晓,刘维永,胡军,等.人甘露糖结合凝集素在小鼠肝脏细胞内表达[J].2002,(12).
[7]卜令真,张士璀.甘露糖结合凝集素在先天性免疫中的作用[J].2013,(3).
[8]黄小敏,陈永连,柳晓春,等.阴道局部甘露糖结合凝集素浓度及其基因多态性与细菌性阴道病的相关性研究[J].2011,(23).
[9]O, Neth,D L, Jack,A W, Dodds,etc.Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition.[J].2000,68(2).
[10]Kurtzhals JA,Madsen HO,Garred P,etc.Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein.[J].1995,155(6).
[11]R, Malhotra,S, Thiel,K B, Reid,etc.Human leukocyte C1q receptor binds other soluble proteins with collagen domains.[J].1990,172(3).
[12]M, Kuhlman,K, Joiner,R A, Ezekowitz.The human mannose-binding protein functions as an opsonin.[J].1989,169(5).
[13]Kilpatrick DC.Mannan-binding lectin and its role in innate immunity.[J].2002,12(6).
[14]Kazue, Takahashi,R Alan B, Ezekowitz.The role of the mannose-binding lectin in innate immunity.[J].2005,41 Suppl 7.
[15]Edmond Chada Baracat,Lana Maria de Aguiar,Iara Moreno Linhares,etc.Association between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis.[J].2012,285(1).
[16]J C, Jensenius,P H, Jensen,K, McGuire,etc.Recombinant mannan-binding lectin (MBL) for therapy.[J].2003,31.
[17]Roos A,Roep BO,Bouwman LH.Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity.[J].2006,67(4).
[18]Koch C,Vorup-Jensen T,Thiel S,etc.Control of the classical and the MBL pathway of complement activation.[J].2000,37(14).
[19]Bojan, Nedovic,Brunella, Posteraro,Emanuele, Leoncini,etc.Mannose-binding lectin codon 54 gene polymorphism and vulvovaginal candidiasis: a systematic review and meta-analysis.[J].2014,2014.
[20]Fei Liu,Qinping Liao,Zhaohui Liu.Mannose-binding lectin and vulvovaginal candidiasis[J].2006,92(1).
[21]Giraldo PC,Babula O,Goncalves AK,etc.Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis.[J].2007,109(5).
[22]De Santo D,Radillo O,Durigutto P,etc.Mannose-binding lectin is produced by vaginal epithelial cells and its level in the vaginal fluid is influenced by progesterone.[J].2010,48(1).
[23]Axelsen M,Clemons KV,Thiel S,etc.Efficacy of recombinant human mannose binding lectin alone and in combination with itraconazole against murine Candida albicans vaginitis.[J].2011,40(6).
[24]Jensenius JC,Fujita T,Thiel S,etc.Proteolytic activities of two types of mannose-binding lectin-associated serine protease.[J].2000,165(5).
[25]Tas SW,Nicholson-Weller A,Ghiran I,etc.Complement receptor 1/CD35 is a receptor for mannan-binding lectin.[J].2000,192(12).
[26]Donders GG,Babula O,Bellen G,etc.Mannose-binding lectin gene polymorphism and resistance to therapy in women with recurrent vulvovaginal candidiasis.[J].2008,115(10).
[27]Thiel S,Matthiesen F,Agger T,etc.Phase I safety, tolerability, and pharmacokinetic study of recombinant human mannan-binding lectin.[J].2006,26(5).