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抗苗勒管激素的相关影响因素研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Obstetrics and Gynecology

Issue:: 5

DOI:: 10.3760/cma.j.issn.0529-567x.2015.05.014

Key Word:: No keyword available

Abstract：抗苗勒管激素（anti-Mullerian hormone, AMH），也被称为苗勒管抑制物质（Mullerian inhibition substance, MIS），是1种肽类生长因子，属于组织生长因子β超家族[1]。在女性， AMH特异性地由始基卵泡池内启动生长后的卵泡中的颗粒细胞产生，主要由窦前卵泡和小窦状卵泡分泌[2]，从原始卵泡起持续到卵泡直径约8 mm时停止，其在较大的窦状卵泡中的水平非常低[3]，在FSH依赖的优势卵泡中和闭锁卵泡中均无AMH形成；其主要的生理作用是在卵泡募集早期起调控作用，抑制卵泡从始基卵泡到窦状卵泡的初级募集[4]。颗粒细胞分泌到卵泡液中的AMH可进入血液循环，故取血清标本可检测AMH。

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