Abstract： Objective To evaluate the optimal management of cardiac surgery during pregnancy,and the maternal and fetal outcomes in pregnant patients undergoing cardiac surgery with the use of cardiopulmonary bypass.Methods Nine pregnant women with heart diseases were identified,who underwent cardiac surgery with cardiopulmonary bypass between January 2002 and March 2013.Patient charts were reviewed for pregnant age,types of heart diseases,surgical indication,parameters of cardiopulmonary bypass,and maternal and fetal outcomes.Results Among 9 patients,there were 4 cases of valvular heart disease (two of rheumatic heart disease complicated with subacute bacterial endocarditis and heart failure,one of mechanical prosthetic valves flap after mitral replacement,one of severe aortic stenosis),one case of aortic dissection,three cases with atrial myxoma,and one case with tetralogy of Fallot.The New York Heart Association (NYHA) functional classification: there were three cases with class Ⅰ,two with class Ⅱ,two with class Ⅲ,and two with class Ⅳ.Heart surgeries were performed from 9 to 39 weeks gestation.Five patients underwent heart surgery with cardiopulmonary bypass combined with cesarean section.The other 4 patients terminated pregnancies after heart surgeries,two of whom underwent uterine curettage in first trimester,one induction of labor in second trimester,and one continued to be pregnant until 37 weeks' gestation.Seven patients were alive.Nine fetal outcomes were included two with artificial abortion,one with induction of labor and one with cesarean section in second trimester,two of premature labor and three of full-term labor with cesarean section in third trimester.Five newborns were no malformation,four of whom were alive.Conclusion Cardiopulmonary bypass can be used safely with satisfactory maternal and fetal outcomes in pregnant patients with heart disease undergoing cardiac surgery.