You Position: Home > Paper
术中放疗在子宫颈癌中的应用
( views:442, downloads:180 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Obstetrics and Gynecology
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.0529-567x.2013.09.021
- Key Word:
- No keyword available
Abstract： 在全球女性恶性肿瘤中,子宫颈癌的发病率居第2位,仅次于乳腺癌[1].尽管早期(Ⅰa～ Ⅰb2期)子宫颈癌的预后相对较好,5年生存率可达90％,但晚期子宫颈癌的预后较差,特别是局部晚期或局部复发性子宫颈癌的5年生存率仅为25％ ～ 30％[2-4],其中60％的晚期或复发性子宫颈癌患者死于肿瘤局部控制的失败[4].对术后局部复发、放疗后中心型复发的子宫颈癌,手术是主要治疗方式之一,但前期手术或放疗所致的盆腔粘连、肿瘤的浸润性生长,均限制了肿瘤切除的彻底性,而放疗可作为针对残留肿瘤有效的补充治疗手段.由于局部晚期子宫颈癌的瘤床及复发性子宫颈癌的复发部位均主要局限于盆腔,术中盆腔定位放疗对肿瘤的治疗确切有效,且能有效保护周围正常组织,是很好的补充治疗手段.
- [1]周芙玲,李明众,刘孜.Ⅱb期宫颈癌术中放疗94例[J].2005,(8).
- [2]H M, Shingleton,S J, Soong,M S, Gelder,etc.Clinical and histopathologic factors predicting recurrence and survival after pelvic exenteration for cancer of the cervix.[J].1989,73.
- [3].Global cancer statistics[J].2011,61(2).
- [4]Eifel PJ,Winter K,Morris M,etc.Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01.[J].2004,22(5).
- [5]G R, Garton,L L, Gunderson,M J, Webb,etc.Intraoperative radiation therapy in gynecologic cancer: the Mayo Clinic experience.[J].1993,48(3).
- [6]M J, Webb,R E, Symmonds.Site of recurrence of cervical cancer after radical hysterectomy.[J].1980,138.
- [7]Brandon M, Barney,Ivy A, Petersen,Sean C, Dowdy,etc.Intraoperative Electron Beam Radiotherapy (IOERT) in the management of locally advanced or recurrent cervical cancer.[J].2013,8.
- [8]Gemignani ML,Alektiar KM,Leitao M,etc.Radical surgical resection and high-dose intraoperative radiation therapy (HDR-IORT) in patients with recurrent gynecologic cancers.[J].2001,50(3).
- [9]Asbell S,Greven K,Jhingran A,etc.Extended-field irradiation and intracavitary brachytherapy combined with cisplatin chemotherapy for cervical cancer with positive para-aortic or high common iliac lymph nodes: results of ARM 1 of RTOG 0116.[J].2007,68(4).
- [10]M A, Mahé,J P, Gérard,J B, Dubois,etc.Intraoperative radiation therapy in recurrent carcinoma of the uterine cervix: report of the French intraoperative group on 70 patients.[J].1996,34.
- [11]Tahir Ijaz,Patricia J. Eifel,Thomas Burke,etc.Radiation Therapy of Pelvic Recurrence after Radical Hysterectomy for Cervical Carcinoma[J].1998,70(2).
- [12]J E, Tepper,L L, Gunderson,E, Orlow,etc.Complications of intraoperative radiation therapy.[J].1984,10(10).
- [13]Krengli,M.,Calvo,F.A.,Sedlmayer,F.,etc.Clinical and technical characteristics of intraoperative radiotherapy: Analysis of the ISIORT-Europe database[J].2013,189(9).
- [14]Li Y,Xu H,Yuan J,etc.The outcome of laparoscopic radical hysterectomy and lymphadenectomy for cervical cancer: a prospective analysis of 295 patients.[J].2008,15(10).
- [15]G R, Garton,L L, Gunderson,M J, Webb,etc.Intraoperative radiation therapy in gynecologic cancer: update of the experience at a single institution.[J].1997,37.
- [16]L L, Gunderson.Rationale for and results of intraoperative radiation therapy.[J].1994,74(2).