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HLA-DRB1基因多态性与内异症发病关系的研究
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Obstetrics and Gynecology
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.0529-567x.2012.10.016
- Key Word:
- No keyword available
Abstract： 内异症在育龄期妇女中发病率为10％～15％,近年来发病率有上升趋势.由于内异症发病原因和发病机制迄今不明,故现成为研究的热点.1997年,Gaetje等[1]首次提出内异症是一种自身免疫性疾病,从此,对内异症发病的免疫学研究涉及白细胞免疫的各个方面.研究最多的是人类白细胞抗原(human leukocyte antigen,HLA).HLA系统中,DR抗原是异基因免疫反应中最重要的抗原之一,决定主要编码基因DRB1位点的特异性,DRB1基因多态性与多种免疫功能和白身免疫性疾病的发生有关[2].
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