You Position: Home > Paper
组织因子与子宫内膜异位症相关性的研究进展
( views:624, downloads:280 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Obstetrics and Gynecology
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.0529-567x.2011.11.019
- Key Word:
- No keyword available
Abstract： 育龄女性子宫内膜异位症(内异症)发病率为6％～10％,内异症为子宫内膜组织(腺体和间质)在子宫腔以外的部位生长、浸润、反复出血,形成结节及包块,可引起盆腔痛或不孕等.临床表现与恶性肿瘤类似,出现局部或远处转移、侵袭、破坏其他器官.目前,内异症病因尚未明确,广为接受的是Sampson[1]的“经血逆流种植学说”,还可能与基因、炎症、局部微环境、免疫、类固醇激素代谢失调及内膜本身的异常密切相关[2].近年来研究证实,组织因子( tissuefactor,TF)与恶性肿瘤的生物学行为关系密切,而内异症患者的在位、异位内膜中TF也呈异常高表达,TF参与内异症的炎症、血管生成等病理过程,类似其在恶性肿瘤中发挥的作用.本文就TF参与内异症的病理生理作一综述.
- [1]T, Luther,C, Fl?ssel,N, Mackman,etc.Tissue factor expression during human and mouse development.[J].1996,149(1).
- [2]John A. Sampson.Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity[J].1927,14(4).
- [3]Serdar E. Bulun.Endometriosis[J].2009,360(3).
- [4]van Bergen-En-Henegouwen-PM,van Deventer-SJ,Diks SH,etc.Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac.[J].2000,275(37).
- [5]Steinhoff M,Mitchell SE,Caughey GH,etc.Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism.[J].2000,6(2).
- [6]Hirata T,Morimoto C,Koga K,etc.Possible involvement of thrombin/protease-activated receptor 1 system in the pathogenesis of endometriosis.[J].2005,90(6).
- [7]Lockwood C. J..Steroid-modulated stromal cell tissue factor expression: a model for the regulation of endometrial hemostasis and menstruation [published erratum appears in J Clin Endocrinol Metab 1993 Dec; 77(6):1725-6][J].1993.
- [8]Schaffner F,Ruf W.Tissue factor and protease-activated receptor signaling in cancer.[J].2008,34(2).
- [9]Murk W,Kayisli UA,Uz YH,etc.Increased c-Jun N-terminal kinase activation in human endometriotic endothelial cells.[J].2011,135(1).
- [10]Liu X,Nie J,Guo SW.Elevated immunoreactivity to tissue factor and its association with dysmenorrhea severity and the amount of menses in adenomyosis.[J].2011,26(2).
- [11]Krikun G,Casagrande F,Lockwood CJ,etc.hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma.[J].2010,103(6).
- [12]Torres M,Johnson MC,Sovino H,etc.Nuclear factor kappaB pathway and interleukin-6 are affected in eutopic endometrium of women with endometriosis[J].2009,137(4).
- [13]Taketani Y,Osuga Y,Hirota Y.Basic and translational research on proteinase-activated receptors: proteinase-activated receptors in female reproductive tissues and endometriosis.[J].2008,108(4).
- [14]Zhiwei, Hu,Jing, Li.Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer.[J].2010,11.
- [15]Felding-Habermann B,Kerver M,Takada Y,etc.Inhibition of tissue factor signaling suppresses tumor growth.[J].2008,111(1).
- [16]Krikun G,Hu Z,Osteen.The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis.[J].2010,176(2).
- [17]Krikun G,Huang SJ,Lockwood CJ,etc.Decidualized human endometrial stromal cells mediate hemostasis, angiogenesis, and abnormal uterine bleeding.[J].2009,16(2).
- [18]Charles J. Lockwood,Hugh Taylor,Graciela Krikun,etc.Endometriosis and Tissue Factor[J].2008,1127(0).
- [19]Francis JL,Lwaleed BA,Bass PS.Urinary tissue factor: a potential marker of disease.[J].1999,188(1).