You Position: Home > Paper
白术内酯Ⅰ拮抗TLR4/MyD88信号通路介导的卵巢癌细胞IL-6的分泌及增强紫杉醇诱导的卵巢癌细胞生长的抑制作用
( views:383, downloads:172 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.0529-567x.2011.04.013
- Key Word:
- No keyword available
Abstract： @@ 卵巢癌细胞异常表达Toll样受体4(TLR4)和髓样分化因子88(MyD88)可能与患者预后差和无进展生存期较短有关,也可能是紫杉醇化疗抵抗的机制之一.有研究证实,紫杉醇和脂多糖具有一个共同的结合位点TLR4 [1-4].紫杉醇作为TLR4的配体可模拟脂多糖结合TLR4,活化TLR4/MyD88信号通路,上调卵巢癌细胞中白细胞介素6(IL-6)和抗凋亡蛋白的表达,促进卵巢癌细胞的增殖,抵抗紫杉醇的促凋亡作用[5].
- [1]LI Cuiqin,He Langchong.Establishment of the model of white blood cell membrane chromatography and screening of antagonizing TLR4 receptor component from Atractylodes macrocephala Koidz[J].2006,(2).
- [2]Liu PS,Wu FX,Zhang XL,etc.Role of TLR4 for paclitaxel chemotherapy in human epithelial ovarian cancer cells.[J].2009,39(2).
- [3]Li FZ.,Bernacki RJ.,Brattain MG.,etc.Induction of survivin expression by taxol (paclitaxel) is an early event, which is independent of taxol-mediated G(2)/M arrest[J].2004,279(15).
- [4]Kryczek I,Karabon L,Klimczak A,etc.IL-6 production in ovarian carcinoma is associated with histiotype and biological characteristics of the tumour and influences local immunity.[J].2000,82(3).
- [5]N H, Obata,K, Tamakoshi,K, Shibata,etc.Effects of interleukin-6 on in vitro cell attachment, migration and invasion of human ovarian carcinoma.[J].1900,17.
- [6]Bowen KA,Jackson LA,Doan HQ.Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells.[J].2009,29(7).
- [7]Czystowska,Szajnik M,Szczepanski MJ.TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer.[J].2009,28(49).
- [8]C A, Byrd-Leifer,E F, Block,K, Takeda,etc.The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol.[J].2001,31(8).