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荧光定量-聚合酶链反应技术产前快速诊断染色体异常的临床应用
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:0529-567x.2007.05.014
- Key Word:
- No keyword available
Abstract： @@ 预防重大出生缺陷已经成为社会及每个家庭最关注的问题之一.大多数染色体异常为21、13、18号染色体及性染色体的非整倍体异常,占高风险人群的99.8%～99.9%.血清筛查结果为高风险及年龄在35岁以上的孕妇均需进行产前诊断.而产前诊断染色体异常的传统方法是核型分析,染色体核型分析结果一般需要2～3周.荧光定量-聚合酶链反应(FQ-PCR)技术通过对染色体等位基因多态位点上的重复序列扩增来检测染色体数目,24～48 h即可给出诊断结果,缩短了从检测到终止妊娠的时间,为缓解孕妇压力及决定是否终止妊娠争取了宝贵的时间.现将结果报道如下.
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