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妊娠肝内胆汁淤积症患者胎盘组织缺氧及复氧时缺氧诱导因子1α表达水平的变化
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:0529-567X.2007.01.015
- Key Word:
- No keyword available
Abstract： @@ 缺氧诱导因子1α(HIF-1α)是一种重要的转录调节因子,在低氧应答反应中起关键作用,其蛋白水平的变化受细胞氧分压的严密调节,对于低氧环境中机体的生存具有重要意义.妊娠肝内胆汁淤积症(ICP)引起胎儿宫内缺氧的病因及发病机理至今尚不清楚.我们已有的研究支持ICP患者的胎儿缺氧是急性缺氧[1].本研究主要探讨ICP患者急性缺氧及复氧时胎盘组织中的HIF-1α mRNA及蛋白表达的变化及临床意义.
- [1]王冬梅,朱启英,丁丽,等.妊娠肝内胆汁淤积症患者胎盘细胞凋亡及调控基因的研究[J].2003,(1).
- [2]王晓东,刘淑芸,衡正昌.妊娠肝内胆汁淤积症胎儿宫内缺氧机理的初步探讨[J].1998,(2).
- [3]夏松云,陈竹钦,李力.妊娠肝内胆汁淤积症患者高水平胆汁酸对血管内皮细胞生长因子的作用[J].2002,(11).
- [4]Prakobphol A,Foulk R,Genbacev O,etc.Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface.[J].2004,114(6).
- [5]张耀,刘濒芸,王晓东.妊娠肝内胆汗淤积症患者胎儿缺氧的影响因素[J].2000,(10).
- [6]Pan Y,Oprysko PR,Asham AM,etc.P53 Cannot Be Induced by Hypoxia Alone but Responds to the Hypoxic Microenvironment.[J].2004,23(29).
- [7]D M, Nelson,R D, Johnson,S D, Smith,etc.Hypoxia limits differentiation and up-regulates expression and activity of prostaglandin H synthase 2 in cultured trophoblast from term human placenta.[J].1999,180(4).