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Expression of midkine in eutopic and ectopic endometrium of patients with severe endometriosis and its clinical significance
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:0529-567X.2006.05.004
- Key Word:
- 子宫内膜异位症;细胞因子类;新生血管化,病理性;子宫内膜
Abstract： 目的探讨中期因子(MK)蛋白在重度子宫内膜异位症(内异症)患者异位和在位内膜组织中的表达变化及其临床意义.方法应用免疫组化链霉菌抗生物素蛋白-过氧化物酶连接(SP)法,检测41例重度内异症患者(研究组)的异位内膜和在位内膜组织及32例子宫肌瘤患者(对照组)的内膜组织中MK蛋白表达和微血管密度(MVD).结果研究组异位内膜组织中MK蛋白的阳性表达率为29%(12/41),在位内膜组织中MK蛋白的阳性表达率为63%(26/41),对照组内膜组织中MK蛋白的阳性表达率为22%(7/32),研究组在位内膜组织中MK蛋白阳性表达率与异位内膜组织及对照组内膜组织比较,差异均有统计学意义(P均＜0.05),而且两组MK蛋白的阳性表达率与MVD呈正相关关系(r=0.637,P＜0.05).结论MK蛋白在重度内异症患者的在位内膜过度表达,且与内膜血管生成密切相关.在位内膜中MK蛋白的表达变化可能与重度内异症的发生、发展有关.
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