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Studies on the relationship between unexplained recurrent spontaneous abortion and immunotolerance at the maternal-fetal interface
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:0529-567X.2006.03.001
- Key Word:
- No keyword available
Abstract： @@ 原因不明复发性流产(URSA)是指与同一性伴侣连续发生3次或3次以上自然流产,且不存在染色体、解剖、内分泌和自身免疫异功能常以及生殖道感染等病因.生殖免疫学观点认为,正常胚胎不被母体排斥有赖于母-胎界面的免疫耐受,一旦这种免疫耐受格局被打破,将导致URSA的发生.免疫调节是一种精细、复杂、在不同水平由多因素参与的免疫生物学现象.目前国内外最新的研究也表明,URSA所表现的母-胎界面免疫耐受异常与人类白细胞抗原(HLA)调节异常及自然杀伤(NK)细胞、T淋巴细胞、巨噬细胞和树突状细胞(DC)等多种免疫职能细胞的功能异常、细胞凋亡以及细胞因子表达异常等多因素有关.
- [1]金莉萍,李大金,王明雁,等.妊娠早期阻断协同刺激分子诱导自然流产模型孕鼠脾脏细胞母-胎免疫耐受的研究[J].2004,(4).
- [2]Margni RA,Alba Soto CD,Gentile T,etc.Therapy with dendritic cells influences the spontaneous resorption rate in the CBA/J x DBA/2J mouse model.[J].2004,51(1).
- [3]L A, Stephens,C, Mottet,D, Mason,etc.Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro.[J].2001,31(4).
- [4]B J, Fowlkes,A M, Kruisbeek,H, Ton-That,etc.A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family.[J].1900,329.
- [5]Min-Min Yuan,Li-Ping Jin,Da-Jin Li,etc.Human First-Trimester Trophoblast Cells Recruit CD56~(bright)CD16~- NK Cells into Decidua by Way of Expressing and Secreting of CXCL12/Stromal Cell-Derived Factor 1[J].2005,175(1).
- [6]Hammer A,Dohr G.Apoptotic nuclei within the uterine decidua of first trimester pregnancy arise from CD45 positive leukocytes.[J].1999,42(2).
- [7]Sekikawa K,Akasaka T,Kondo E,etc.Involvement of decidual Valpha14 NKT cells in abortion.[J].2000,97(2).
- [8]Wang X,Lin Q,Hong Y,etc.The skewed TCR-BV repertoire displayed at the maternal-fetal interface of women with unexplained pregnancy loss.[J].2005,54(2).
- [9]Clark DA,Croitoru K.TH1/TH2,3 imbalance due to cytokine-producing NK, gammadelta T and NK-gammadelta T cells in murine pregnancy decidua in success or failure of pregnancy.[J].2001,45(5).