You Position: Home > Paper
Expression of Fas antigen and ligand, placental growth factor in placenta of pregnant women with pre-eclampsia
( views:264, downloads:131 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:0529-567X.2005.05.010
- Key Word:
- 子痫前期;抗原,CD95;膜糖蛋白类;妊娠蛋白质类
Abstract： 目的探讨Fas抗原(Fas)及其配体(FasL)、胎盘生长因子(PlGF)在子痫前期患者胎盘合体滋养细胞中的表达变化及其意义.方法采用免疫组化链霉菌抗生物素蛋白-过氧化物酶(SP)连接法检测24例正常晚期妊娠妇女(正常晚孕组)、24例轻度子痫前期产妇(轻度子痫前期组)及24例重度子痫前期产妇(重度子痫前期组)胎盘组织中Fas、FasL及PlGF表达水平.结果Fas、FasL及PlGF主要表达于胎盘合体滋养细胞胞质及胞膜中.FasL、PlGF在轻度子痫前期组(63±4、81±6)及重度子痫前期组(42±6、65±6)胎盘中的表达均低于正常晚孕组(73±9、88±8),分别与正常晚孕组比较,差异均有统计学意义(P<0.01).Fas在轻度子痫前期组(51±4)及重度子痫前期组(67±6)胎盘中的表达均高于正常晚孕组(43±6),分别与正常晚孕组比较,差异均有统计学意义(P<0.01).结论 Fas、FasL及PlGF在子痫前期胎盘合体滋养细胞中表达失衡,可能与子痫前期的发病及发展有关.
- [1]刘伟,林其德,王立东,等.胎盘生长因子与妊娠高血压综合征发病的相关性研究[J].2001,(1).
- [2]L, Owen-Schaub.Soluble Fas and cancer.[J].2001,7.
- [3]Günter Reinhard,Arno Noll,Harald Schlebusch,etc.Shifts in the TH1/TH2 Balance during Human Pregnancy Correlate with Apoptotic Changes[J].1998,245(3).
- [4]Schisterman EF,Levine RJ,Maynard SE,etc.Circulating angiogenic factors and the risk of preeclampsia.[J].2004,350(7).
- [5]Oleszczuk J,Rolinski J,Leszczynska-Gorzelak B,etc.The expression and concentrations of Fas/APO-1 (CD95) antigen in patients with severe pre-eclampsia.[J].2001,49(2).
- [6]B Coumans,O Thellin,W Zorzi,etc.Lymphoid cell apoptosis induced by trophoblastic cells: a model of active foeto-placental tolerance[J].1999,224(1-2).
- [7]乐杰.妇产科学[M].2004.