You Position: Home > Paper
卵巢癌细胞中CD44的表达及其反义寡核苷酸抑制卵巢癌细胞黏附侵袭的实验研究
( views:127, downloads:8 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:0529-567X.2004.05.020
- Key Word:
- No keyword available
Abstract： @@ 卵巢癌是我国最常见的妇科恶性肿瘤之一,70%的患者确诊时已届晚期,故5年生存率极低.腹膜种植、转移是卵巢癌细胞转移的主要方式,也是卵巢癌患者致死的主要原因[1].CD44是目前研究较多的腹膜转移相关黏附分子,它主要介导细胞与细胞、细胞与基质之间的黏附,进而参与肿瘤的侵袭和转移.我们尝试以CD44反义寡核苷酸(antisense oligodeoxynucleotide,ASODN)体外转染卵巢癌细胞系CAOV3,观察其对癌细胞黏附和侵袭能力的影响.
- [1]S A, Cannistra,G S, Kansas,J, Niloff,etc.Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H.[J].1993,53.
- [2]高进.癌的侵袭与转移[M].1995.
- [3]曹泽毅主编.中华妇产科学[M].1999.
- [4]K, Lessan,D J, Aguiar,T, Oegema,etc.CD44 and beta1 integrin mediate ovarian carcinoma cell adhesion to peritoneal mesothelial cells.[J].1999,154.