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子宫内膜癌组织中磷酸化蛋白激酶B及Bim蛋白表达的研究
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 12
- DOI:
- 10.3760/j.issn:0529-567X.2003.12.017
- Key Word:
- No keyword available
Abstract： @@ 3-羧基磷脂酰肌醇激酶(PI3K)/蛋白激酶B (PKB)信号转导途径是调控细胞凋亡的重要途径,PKB是PI3K的下游因子,PKB磷酸化激活后,可通过对多种凋亡相关因子的调节来抑制细胞凋亡.Bim为bcl-2蛋白家族中仅含有BH3区域的成员之一.有研究表明,活化的PKB可通过作用BH3区域,进而抑制bcl-2家族相关蛋白的促凋亡活性[1].目前,国外有关Bim基因表达的研究多集中在造血干细胞及粒细胞[2],在子宫内膜癌方面的研究尚少.本研究对子宫内膜癌组织的磷酸化PKB(p-PKB)与Bim蛋白表达水平进行检测,并探讨其与子宫内膜癌发生的关系.
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