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阿克拉霉素与顺铂联合应用对卵巢癌细胞的抑制作用
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:0529-567X.2003.04.021
- Key Word:
- No keyword available
Abstract： @@ 卵巢癌化学药物治疗(化疗)中,顺铂(CDDP)的应用十分普遍,但其抗药性问题也日渐突出,因此,选择能有效与之配伍的药物,是提高CDDP疗效的关键问题之一.阿克拉霉素(ACR)作为拓扑异构酶Ⅱ(topoisomeraseⅡ,topoⅡ)抑制剂之一,在卵巢癌的治疗中使用较少,并且与其他抗癌药物联合应用时,相互作用机理尚不明确.本研究通过ACR与CDDP联合应用的体外实验,探讨卵巢癌化疗药物的合理组配,为筛选有效抗肿瘤药物提供依据.
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