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系统性红斑狼疮与妊娠

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY

Issue:: 3

DOI:: 10.3760/j.issn:0529-567X.2003.03.019

Key Word:: No keyword available

Abstract： @@ 系统性红斑狼疮(SLE)是一种多脏器多系统损害并伴多种免疫学指标异常的自身免疫性疾病.好发于生育期女性,虽不影响女性患者的生育能力,但可影响胎儿.妊娠又可诱发SLE复发或恶化,SLE与妊娠可相互影响.近年来,SLE女性患者妊娠已不视为禁忌,SLE与妊娠关系怎样,什么条件下允许妊娠,如何及时控制SLE病情等,是临床医生应探讨和解决的问题.一、SLE对妊娠的影响SLE对妊娠经过有很大影响,使孕妇处于高危状态,易发生流产、妊娠高血压综合征(妊高征)、早产、胎死宫内及胎儿生长受限(FGR).Rahman等[1]对73例SLE孕妇的141次妊娠研究表明,60.1%为活产,23.8%为自然流产,2.2%为死胎,14.0%发生治疗性流产;在活产中,24.4%是早产儿,7.9%胎儿发生FGR,3.0%有新生儿狼疮(NLE),2.3%有先天畸形,2.3%早期新生儿死亡.

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