Impact of high response of ovary to gonadotropin stimulation on the outcome of in vitro fertilization and embryo transfer or intracytoplasmic sperm injection
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 10
- DOI:
- 10.3760/j.issn:0529-567X.2002.10.008
- Key Word:
- 超排卵;精子注射,细胞质内;受精,体外;卵植入;卵巢过度刺激综合征;妊娠结局
Abstract： 目的探讨超排卵周期中卵巢反应性与体外受精(IVF)、卵胞浆内单精子注射(ICSI)结局的关系.方法回顾分析1999年3月至2000年12月间,474对不孕夫妇在本中心按常规方法行IVF-胚胎移植(ET)及ICSI治疗的510个周期.采用促性腺激素释放激素激动剂(GnRH-a)/高纯促卵泡激素(FSH-HP)/人绒毛膜促性腺激素(hCG)长、短方案促排卵,以注射hCG日血清雌二醇(E2)>11 010 pmol/L(160个周期)为A组,获卵数>15个(148个周期)为B组,A、B两组为卵巢高反应组;E2≤11 010 pmol/L(350个周期)为C组,获卵数≤15个(362个周期)为D组,C、D两组为正常反应组.结果高反应组与低反应组间,年龄、不孕时间、基础FSH水平及FSH用量差异有显著性(P<0.01,P<0.05).A组着床率、妊娠率分别为18.9%(94/498)与38.8%(62/160),C组分别为20.7%(212/1 026)与 41.4%(145/350),两组比较,差异无显著性(P>0.05);B组分别为22.5%(103/457)与46.6%(69/148),D组分别为19.0%(203/1 067)与38.1%(138/362),两组比较,差异无显著性(P>0.05).卵巢过度刺激综合征(OHSS)发生率,A组为6.9%(11/160),C组为2.6%(9/350),B组为8.1%(12/148),D组为2.2%(8/362),A组与C组比较、B组与D组比较,差异均有极显著性(P<0.01).结论高E2水平或获取多个卵子不影响IVF、ICSI的结果,但OHSS发生率高.
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