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子宫内膜癌患者外周血中基质金属蛋白酶-9的表达
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 7
- DOI:
- 10.3760/j.issn:0529-567X.2002.07.022
- Key Word:
- No keyword available
Abstract： @@ 细胞外基质的降解,是肿瘤侵袭正常组织和开始转移的重要信号及途径,这一降解过程主要依赖蛋白水解酶.基质金属蛋白酶(matrix metalloproteinases, MMPs)是一类重要的蛋白水解酶及能分解纤维类胶原的酶[1], 对细胞外基质有广泛的降解作用.本研究拟通过对子宫内膜癌患者外周血单核细胞中MMP-9 mRNA表达的定量研究,探讨MMP-9在子宫内膜癌的发生、浸润和转移过程中的表达及调控机制.
- [1]Shlomo Shimonovitz,Arye Hurwitz,Drorit Hochner-Celnikier,etc.Expression of gelatinase B by trophoblast cells: Down-regulation by progesterone[J].1998,178(3).
- [2]Ebihara, I.,Nakamura, T.,Tomino, Y.,etc.Metalloproteinase-9 mRNA Expression in Monocytes from Patients with Chronic Renal Failure[J].1998,18(4).