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Expression and role of placental vascular endothelial growth factor in patients with pregnancy induced hypertension
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:0529-567X.2002.01.008
- Key Word:
- 妊娠并发症,心血管;高血压;淋巴因子;内皮生长因子;胎盘
Abstract： 目的探讨胎盘血管内皮生长因子(VEGF)在妊娠高血压综合征(妊高征)患者中的表达及其与胎盘血管网络构建、胎盘重量及新生儿体重的关系.方法采用蛋白免疫印迹技术测定25例正常妊娠妇女(正常妊娠组)及25例妊高征患者(妊高征组)的胎盘组织中VEGF的表达.采用免疫组织化学法,用抗F8因子抗体标记两组孕妇胎盘中的血管密度.两组孕妇分娩后,测量新生儿身长、体重,并胎盘称重.结果 (1)妊高征组和正常妊娠组孕妇胎盘VEGF积分吸光度值分别为24 793±6 579、41 903±11 009;胎盘血管密度分别为(61±11)和(78±11)个/400×视野.两组比较,差异均有极显著性(P<0.01),且与妊高征患者病情严重程度相关.(2)妊高征组胎盘重量[(460±59) g]较正常妊娠组[(573±99) g]显著下降(P<0.01).(3)妊高征组新生儿体重为(3 176±503) g,较正常妊娠组的(3 468±493) g显著下降(P<0.05);而新生儿身长在两组间比较,差异无显著性(P>0.05).(4)正常妊娠组中,胎盘VEGF的表达与血管密度、胎盘重量和新生儿体重的相关系数分别为0.823、0.671、0.888;妊高征组分别为0.905、0.859、0.732,两者均呈显著正相关(P<0.01).而VEGF表达与新生儿身长不相关(P>0.05).结论妊高征患者胎盘VEGF表达下降,可能是其胎盘血管密度降低导致胎儿生长受限的原因之一.
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