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Expression of human leucocyte antigen in ectopic endometrial tissue of endometriosis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 8
- DOI:
- 10.3760/j.issn:0529-567X.2001.08.008
- Key Word:
- 子宫内膜异位症;HLA抗原
Abstract： 目的探讨人类白细胞抗原(HLA)分子在异位子宫内膜中的表达及其在子宫内膜异位症(内异症)发病机理中的作用.方法采用免疫组织化学染色法测定25例内异症患者(内异症组)异位子宫内膜腺上皮细胞的HLA分子的表达,并用流式细胞术检测其中10例体外培养成功的异位内膜细胞的HLA分子表达.以15例健康育龄妇女的在位子宫内膜为对照(对照组).结果异位子宫内膜腺上皮细胞:(1)HLA-Ⅰ类分子表达下降,对照组和内异症组免疫组织化学染色切片列线图评分分别为(4.0±0.5)和(1.2±0.8)分,体外培养细胞分别为(63.38±11.88)%和(5.27±2.88)%(P＜0.01).(2)HLA-Ⅱ类分子表达增加,对照组和内异症组免疫组织化学染色切片列线图评分分别为(0.2±0.1)和(4.1±0.7)分,体外培养细胞分别为(7.19士2.43)%和(58.57±14.99)%(P_＜0.01).结论异位子宫内膜腺上皮细胞内异常的HLA分子表达可能在内异症发病过程中起一定的作用.
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