Relationship between follicular development and insulin like growth factor Ⅰ receptor in stimulated cycles
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:0529-567X.2001.02.010
- Key Word:
- 受体,胰岛素样生长因子Ⅰ;卵巢滤泡;超排卵
Abstract： Objective To investigate the number of follicles and insulin-like growth factor I receptor (IGF-ⅠR) in stimulated cycles. Method IGF-ⅠR mRNA and IGF-ⅠR in granulosa cells obtained during oocyte retrieval were respectively measured by reverse transcript polymerase chain reaction （RT-PCR） and Western blot technique. Results The expression of IGF-ⅠR mRNA in poor responders (follicles≤3) was much lower than in normal responders (follicles 4～13) and high responders (follicles≥14) (1.70±0.23, 2.92±0.49,4.22±1.50 respectively). Similar results were obtained for IGF-ⅠR (1.32±0.31, 2.01±0.72, 4.39±2.31 respectively). Conclusion The expression of IGF-ⅠR correlated with the effects of gonadotropin hormone on follicular development.
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