Abstract： To the Editor:Kaposiform hemangioendothelioma (KHE) is a rare,locally invasive,vascular tumor of infants and adolescents.It has an annual incidence of approximately 0.071 per 100,000 children.[1,2] KHE has a roughly equal gender ratio.[3] It generally affects the soft tissues presenting as mass lesions with associated cutaneous abnormities and Kasabach-Merritt phenomenon (KMP).[4-6] KHE locating in non-cutaneous sites (such as viscera and retroperitoneum) and those with KMP are reported to be associated with poor prognosis due to a more aggressive disease phenotype.[7] To date,spinal involvement with KHE is rarely encountered in the clinics.A comprehensive review of the literature only identified two cases of spinal KHE occurring in two girls.[4,5] Here,we documented a rare case of KHE of the cervical spine that was successfully treated by surgical resection and thalidomide therapy.