Abstract： To the Editor:Neonatal diabetes mellitus (NDM) is defined as diabetes diagnosed within 6 months after birth and occurs in approximately one in every 90,000 to 160,000 live births,with an 80％ yield due to a known genetic diagnosis.NDM can be classified as transient (TNDM),permanent (PNDM),or syndromic,in which TNDM accounts for approximately 45％ of all cases of NDM.Overexpression of genes on chromosome 6q24 is the most common cause of TNDM (OMIM_601410),which accounts for approximately 70％ of all cases and occurs by one of three mechanisms:(1) paternal uniparental disomy (41％),(2) duplication of paternal alleles (33％),or (3) hypomethylation of the maternal allele (26％).[1] TNDM can be characterized as small for gestational age and yield a “Diabetes-RemissionRelapse” natural history,[2] where insulin is deemed to be the original treatment.However,there is no standard treatment for relapsed patients.Hence,we report a Chinese male patient with a history of 6q24-related TNDM (hypomethylation of the maternal allele) who relapsed at 14 years old and was successfully treated with a low dose of glimepiride.