Abstract： To the Editor: Langerhans cell histiocytosis (LCH) is a rare disease that usually occurs in the first two decades of life.[1] Multisystem-LCH (MS-LCH) mainly affects youth. Bone, lung, and skin are the most common systems involved.[2] Here, we report a case from China of MS-LCH in a 79-year-old patient with bone marrow, liver, spleen, and lung involvement, but without bone and skin involvement.A 79-year-old man with a smoking history of 100 pack-years was admitted to our hospital on August 6, 2015. He complained of shortness of breath and exertional palpitations, accompanied by bloody sputum, of 1 -month duration. The shortness of breath had worsened recently, associated with lethargy and loss of appetite. Five days before admission, he developed yellowish staining in the skin and sclera with occasional abdominal distension. His past medical history included type 2 diabetes for 5 years, thrombocytopenia (70-80 × 109/L) for several years, and idiopathic atrial fibrillation diagnosed 1 month ago. Amiodarone (dosage unknown) was used to control the ventricular rate.