Abstract： A 43-year-old female was admitted to the Department of Nephrology at Jinling Hospital (Nanjing,China) in January 2017 complaining of edema for 3 months with urine abnormalities.Her father had renal disease (with no biopsy performed) when he was 40 years old and died of uremia at 56 years old.Her mother and brother were healthy;however,her daughter and nephew (her brother's son) had slightly high microalbumin levels in routine urine screenings.Her daughter's urinary protein level was weakly positive,whereas her nephew's urinary protein level was negative.