Abstract： INTRODUCTION Common variable immunodeficiency (CVID) is a heterogeneous immunodeficiency syndrome characterized by defective antibody formation.Approximately 70-80％ of patients are diagnosed based on a previous history of recurrent sinus and lung and gastrointestinal infections.The diagnosis is based on the exclusion of other known causes of humoral defects.[1] In addition to infections,the coexisting morbidities in CVID include autoimmunity,malignancies,and autoimmune endocrine diseases.We present a case of CVID in which the coexisting morbidities of amenorrhea were associated with a withdrawal bleed following intravenous immunoglobulin (IVIG) treatment.