Abstract： Background:Locally advanced pancreatic carcinoma (LAPC) is characterized by poor prognosis despite recommended concurrent chemoradiotherapy.Irreversible electroporation (IRE) has emerged as a potential option for the management of unresectable pancreatic cancer.This study was conducted to evaluate the safety and short-term efficacy of open IRE for the treatment of LAPC.Methods:Retrospective data of 25 consecutive patients receiving IRE for T3 lesions from July 2015 to June 2016 at a single center were analyzed.The perioperative and long-term IRE-related complications were reviewed to evaluate the safety of the procedure.The tumor reduction and biological response were analyzed through computed tomography/magnetic resonance imaging;the serum level of CA 19-9 was measured as a secondary endpoint to evaluate the short-term efficacy of IRE.Results:All patients were successfully treated;the median tumor size was 4.2 cm and the median IRE time was 36 min.Four intraoperative procedure-related complications were observed (16％):two transient hypertensive episodes,one hypotension case,and one transient supraventricular tachycardia case.Nine postoperative complications were described,including three Grade A pancreatic fistulas,three delayed gastric emptying,one acute pancreatitis,one upper gastrointestinal hemorrhage,and one portal vein thrombosis.The overall rate of stable disease was 28％,36％ achieved partial response,and lower serum CA19-9 levels were recorded in all patients at discharge.Conclusions:IRE is feasible for the treatment of LAPC and is a reasonable intervention strategy owing to its combined attributes of safety and efficacy.