Paper - WANFANG MED ONLINE

You Position: Home > Paper

Effect of Chinese Herbal Medicine Jinlida Granule in Treatment of Patients with Impaired Glucose Tolerance

( views:105, downloads:16 )

Author:: No author available

Journal Title:: Chinese Medical Journal

Issue:: 19

DOI:: 10.4103/0366-6999.190676

Key Word:: Clinical Observation;Diabetes Mellitus;Impaired Glucose Tolerance;Jinlida Granule

Abstract： Background:Diabetes mellitus (DM) remains a major health problem worldwide.Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM.This study aimed to evaluate the efficacy of Jinlida (JLD) granule,a Chinese herbal recipe,in the treatment of impaired glucose tolerance (IGT) and its effect on the prevention of DM.Methods:Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily (JLD group,n =34) or no drug intervention (control group,n =31) for 12 weeks.Oral glucose tolerance test,glycated hemoglobin A1c (HbA1c),body mass index,blood lipids levels,fasting insulin,and insulin resistance calculated using homeostatic model assessment (HOMA-IR) of all the patients were observed and compared before and after the treatment.Results:Sixty-one participants completed the trial (32 in JLD group and 29 in the control group).There were statistically significant decreases in HbA1c (P ＜ 0.001),2-h plasma glucose (P ＜ 0.001),and HOMA-IR (P =0.029) in JLD group compared with the control group after 12 weeks of treatment.After 12 weeks of treatment,two (6.9％) patients returned to normal blood glucose,and five (17.2％) patients turned into DM in control group,while in the JLD group,14 (43.8％) returned to normal blood glucose and 2 (6.2％) turned into DM.There was a significant difference in the number of subjects who had normal glucose at the end of the study between two groups (P =0.001).Conclusions:JLD granule effectively improved glucose control,increased the conversion of IGT to normal glucose,and improved the insulin resistance in patients with IGT.This Chinese herbal medicine may have a clinical value for IGT.

Reference

[1]Khemayanto Hidayat,SHI Bimin.Role of Mediterranean diet in prevention and management of type 2 diabetes[J].2014,(20).
[2]Xiao-Ling CAI,Ying-Li Chen,Jia-jun ZHAO,etc.Efficacy and Safety of Avandamet or Uptitrated Metformin Treatment in Patients with Type 2 Diabetes Inadequately Controlled with Metformin Alone: A Multicenter, Randomized, Controlled Trial[J].2015,(10).
[3]Tabák,A.G.,Herder,C.,Rathmann,W.,etc.Prediabetes: A high-risk state for diabetes development[J].2012,379(9833).
[4]Hamman RF,Ehrmann DA,Fowler SE,etc.Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program.[J].2005,54(4).
[5]Temprosa M,Ratner R,Haffner S,etc.Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program.[J].2005,28(4).
[6]Xiao, Sun,Liping, Guo,Hongcai, Shang,etc.The cost-effectiveness analysis of JinQi Jiangtang tablets for the treatment on prediabetes: a randomized, double-blind, placebo-controlled, multicenter design.[J].2015,16.
[7]Yu,X.,Zhou,H.,Feng,J.,etc.Clinical research of traditional chinese medical intervention on impaired glucose tolerance[J].2013,41(1).
[8]Tong,X.-L.,Chen,L.,Dong,L.,etc.Treatment of diabetes using traditional Chinese medicine: Past, present and future[J].2012,40(5).
[9]Targher G,Bonora E,Zenere MB,etc.Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.[J].2000,23(1).
[10]Li,Z.,Shangguan,Z.,Liu,Y.,etc.Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway[J].2014,53(1).
[11].Role of Insulin Secretion and Sensitivity in the Evolution of Type 2 Diabetes in the Diabetes Prevention Program: Effects of Lifestyle Intervention and Metformin[J].2005,54(8).
[12].Report of the expert committee on the diagnosis and classification of diabetes mellitus.[J].2003,26 Suppl 1.
[13]Jean-Louis, Chiasson,Robert G, Josse,Ramon, Gomis,etc.Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial.[J].2002,359.
[14]Gerstein HC,Santaguida P,Raina P,etc.Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies.[J].2007,78(3).
[15]Dingkun Wang,Min Tian,Yuan Qi,etc.Jinlida granule inhibits palmitic acid induced-intracellular lipid accumulation and enhances autophagy in NIT-1 pancreatic β cells through AMPK activation[J].2015,161.
[16]Pugh W,Xie JT,Zhang L,etc.Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.[J].2002,51(6).
[17]L Guariguata,D R Whiting,I Hambleton,etc.Global estimates of diabetes prevalence for 2013 and projections for 2035.[J].2014,103(2).
[18]Chen M,Yang Y,Li F,etc.Effects of berberine on glucose metabolism in vitro.[J].2002,51(11).
[19]Knowler WC,Barrett Connor E,Fowler SE,etc.Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.[J].2002,346(6).
[20]Fengmei Lian,Guangwei Li,Xinyan Chen,etc.Chinese Herbal Medicine Tianqi Reduces Progression From Impaired Glucose Tolerance to Diabetes: A Double-Blind, Randomized, Placebo-Controlled, Multicenter Trial[J].2014,99(2).
[21]Michael Bergman.Pathophysiology of prediabetes and treatment implications for the prevention of type 2 diabetes mellitus.[J].2013,43(3).
[22]Gerstein HC,Yusuf S,Bosch J,etc.Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial.[J].2006,368(9541).
[23]Wei, Y.,Hong, Y. z.,Ye, X..Effect of Tang No.1 granule （糖1�?�方） in treating patients with impaired glucose tolerance[J].2008,14(4).
[24]Tajima N,Kaku K,Kawamori R,etc.Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance.[J].2009,373(9675).
[25]Clare L, Gillies,Keith R, Abrams,Paul C, Lambert,etc.Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis.[J].2007,334(7588).
[26]Bennett PH,Gong Q,Li H,etc.The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study.[J].2008,371(9626).
[27]Yu, Xu,Limin, Wang,Jiang, He,etc.Prevalence and control of diabetes in Chinese adults.[J].2013,310(9).
[28]Jaspinder, Kaur.A comprehensive review on metabolic syndrome.[J].2014,2014.
[29]Fodor JG,Adamo KB.Prevention of type 2 diabetes mellitus by changes in lifestyle.[J].2001,345(9).
[30]Fang,Z.,Zhao,J.,Shi,G.,etc.Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: A randomized controlled trial[J].2014,22(5).
[31]Buysschaert M,Bergman M.Definition of prediabetes.[J].2011,95(2).
[32]D R, Matthews,J P, Hosker,A S, Rudenski,etc.Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.[J].1985,28.
[33]Nicola D, Guess,Anne, Dornhorst,Nick, Oliver,etc.A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes.[J].2015,12.