Abstract： Recently,cardiac resynchronization therapy (CRT) with multipoint left ventricular (LV) pacing in a single coronary sinus branch (MultiPointTM Pacing [MPP],St.Jude Medical,Inc.,Sylmar,CA,USA) has been introduced commercially.The CRT system with MPP feature offers a new strategy for physicians to further enhance CRT in patients with heart failure.Early clinical studies have shown that MPP,compared with conventional biventricular (BiV) pacing,provides acute benefits to LV dP/dtmax,[1] LV dyssynchrony,[2] LV peak radial strain,[3] and LV electrical activation,[4] and improves CRT response at 12 months.[5] In this report,we presented two MPP CRT cases in China with acute hemodynamic assessment under various MPP and conventional BiV pacing configurations,demonstrating that MPP can offer further benefits to patients.