Paper - WANFANG MED ONLINE

You Position: Home > Paper

Serum Gamma-glutamyl Transferase Concentration Within the Reference Range is Related to the Coronary Heart Disease Risk Prediction in Korean Men: Analysis of the Korea National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011)

( views:56, downloads:20 )

Author:: No author available

Journal Title:: Chinese Medical Journal

Issue:: 15

DOI:: 10.4103/0366-6999.161343

Key Word:: Framingham Risk Score;Gamma-glutamyl Transferase;Reference Range

Abstract： Background:Limited data exist on the association of serum gamma-glutamyl transferase (GGT) level within the reference range with the increased risk of coronary heart disease (CHD) prediction in men.The study examined the association between serum GGT concentration within the reference range and the CHD risk prediction in Korean men.Methods:The study employed data from Korean National Health and Nutrition Examination Survey (V-1,2010 and V-2,2011) where a total of 1301 individuals were analyzed.A 10-year CHD risk prediction was computed using the Framingham Risk Score (FRS) modified by the National Cholesterol Education Program (NCEP) Adult Treatment Panel Ⅲ (ATP Ⅲ).Results:Positive correlations were established between log-transformed GGT concentration and FRS (r =0.237,P ＜ 0.001).After adjustment of body mass index,the amount of alcohol intake and low-density lipoprotein-cholesterol,the odds ratio (95％ confidence interval) for intermediate risk and beyond of 10-year CHD prediction (10-year risk ≥10％) with lowest quartile of participants was 1.21 (0.78-1.87) for second quartiles,1.39 (0.88-2.21) for third quartiles and 2.03 (1.23-3.34) for highest quartiles.Conclusions:Higher serum GGT within its reference range was significantly correlated with a 10-year CHD risk prediction estimation using NCEP ATP Ⅲ in Korean men.

Reference

[1]I J, Perry,S G, Wannamethee,A G, Shaper.Prospective study of serum gamma-glutamyltransferase and risk of NIDDM.[J].1998,21.
[2]Simona, Bo,Roberto, Gambino,Marilena, Durazzo,etc.Associations between gamma-glutamyl transferase, metabolic abnormalities and inflammation in healthy subjects from a population-based cohort: a possible implication for oxidative stress.[J].2005,11.
[3]Baldi S,Haffner SM,Nannipieri M,etc.Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico city diabetes study.[J].2005,28(7).
[4]Paolicchi A..Human Atherosclerotic Plaques Contain Gamma-Glutamyl Transpeptidase Enzyme Activity[J].2004.
[5]Bentzon,J.F.,Otsuka,F.,Virmani,R.,etc.Mechanisms of plaque formation and rupture[J].2014,114(12).
[6]Tonoli M,Cigolini M,De Sandre G,etc.The white blood cell count: its relationship to plasma insulin and other cardiovascular risk factors in healthy male individuals.[J].1996,239(5).
[7]Douglas S,Lee.Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study.[J].2007,27.
[8]Vaziri ND,Ehdaie A,Barnard RJ,etc.Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome.[J].2006,55(7).
[9]Enrica Golia,Giuseppe Limongelli,Francesco Natale,etc.Adipose tissue and vascular inflammation in coronary artery disease[J].2014,(7).
[10]Matsha, Tandi Edith,Macharia, Muiruri,Yako, Yandiswa Yolanda,etc.Gamma-glutamyltransferase, insulin resistance and cardiometabolic risk profile in a middle-aged African population[J].2014,21(12).
[11]Hyo Jeong, Oh,Tae Hyeon, Kim,Young Woo, Sohn,etc.Association of serum alanine aminotransferase and γ-glutamyltransferase levels within the reference range with metabolic syndrome and nonalcoholic fatty liver disease.[J].2011,17(1).
[12]Park SW,Jo SK,Won JC,etc.Serum gamma-glutamyl transferase activity predicts future development of metabolic syndrome defined by 2 different criteria.[J].2009,403(1).
[13]S.G. Wannamethee,L. Lennon,A.G. Shaper.The value of gamma-glutamyltransferase in cardiovascular risk prediction in men without diagnosed cardiovascular disease or diabetes[J].2008,201(1).
[14]Michele, Emdin,Alfonso, Pompella,Aldo, Paolicchi.Gamma-glutamyltransferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the plaque.[J].2005,112.
[15]Negi S,Anand A.Atherosclerotic coronary heart disease-epidemiology, classification and management.[J].2010,10(4).
[16]J B, Whitfield.Gamma glutamyl transferase.[J].2001,38.
[17]Grzywocz, Patryk,Mizia-Stec, Katarzyna,Wybraniec, Maciej,etc.Adipokines and endothelial dysfunction in acute myocardial infarction and the risk of recurrent cardiovascular events[J].2015,16(1).
[18]Okan,Turgut.Gamma-glutamyltransferase to determine cardiovascular risk: shifting the paradigm forward.[J].2011,18.
[19]Passino C,Pompella A,Emdin M,etc.The significance of serum gamma-glutamyltransferase in cardiovascular diseases.[J].2004,42(10).
[20]Debbie A, Lawlor,Mark, Callaway,Corrie, Macdonald-Wallis,etc.Nonalcoholic fatty liver disease, liver fibrosis, and cardiometabolic risk factors in adolescence: a cross-sectional study of 1874 general population adolescents.[J].2014,99.
[21]Elena GrasseIIi,Andrea D. Compalati,Adriana Voci,etc.Altered oxidative stress/antioxidant status in blood of alcoholic subjects is associated with alcoholic liver disease[J].2014,143.
[22]Maria Franzini,Alessandro Corti,Barbara Martinelli,etc.γ-Glutamyltransferase activity in human atherosclerotic plaques-Biochemical similarities with the circulating enzyme[J].2009,202(1).
[23]Choi NK,Lee WY,Kim I,etc.Longitudinal increase in gamma-glutamyltransferase within the reference interval predicts metabolic syndrome in middle-aged Korean men.[J].2010,59(5).
[24]Liu,X.,Hamnvik,O.-P.R.,Chamberland,J.P.,etc.Circulating alanine transaminase (ALT) and γ-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: The prospective Cyprus Metabolism Study[J].2014,63(6).
[25]Lee,D.-J.,Choi,J.-S.,Kim,K.-M.,etc.Combined effect of serum Gamma-glutamyltransferase and uric acid on Framingham risk score[J].2014,45(4).
[26]Lee D.-H..\u00a0-Glutamyltransferase Is a Predictor of Incident Diabetes and Hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study[J].2003.
[27]T K, Greenfield.Ways of measuring drinking patterns and the difference they make: experience with graduated frequencies.[J].2000,12(1-2).
[28]Kim KN,Kim KM,Lee DJ,etc.Serum gamma-glutamyltransferase concentration correlates with Framingham risk score in Koreans.[J].2011,26(10).
[29]Passino C,Michelassi C,Emdin M.Additive prognostic value of gamma-glutamyltransferase in coronary artery disease.[J].2009,136(1).
[30]Peter Jarcuska,Martin Janicko,Sylvia Drazilová,etc.Gamma-glutamyl transpeptidase level associated with metabolic syndrome and proinflammatory parameters in the young Roma population in eastern Slovakia: a population-based study.[J].2014,22(Suppl.).
[31]Atar,A.I.,Yilmaz,O.C.,Akin,K.,etc.Association between gamma-glutamyltransferase and coronary artery calcification[J].2013,167(4).
[32]Hüseyin, Bozba,Aylin, Y?ld?r?r,Emir, Kara?a?lar,etc.Increased serum gamma-glutamyltransferase activity in patients with metabolic syndrome.[J].2011,39(2).