Abstract： Background:The aim of this research was to investigate the changes in the vision-related resting-state network (V-RSN) in pituitary adenoma (PA) patients after vision improvement,which was induced by operative treatment.Methods:Ten PA patients with an improved visual acuity or/and visual field after transsphenoidal pituitary tumor resection were recruited and underwent a complete neuro-ophthalmologic evaluation,as well as an magnetic resonance imaging (MRI) protocol,including structural and resting-state functional MRI sequences before and after the operation.The regional homogeneity (ReHo) of the V-RSN was evaluated.Two sample t-test was performed to identify the significant differences in the V-RSN in the PA patients before and after transsphenoidal pituitary tumor resection.Results:Compared with the preoperation counterparts,the PA patients with improved vision after the operation exhibited reduced ReHo in the bilateral thalamus,globus pallidus,caudate nucleus,putamen nucleus,supplementary motor area,and left hippocampal formation,and increased ReHo in the bilateral cuneus gyrus,calcarine gyrus,right lingual gyrus,and fusiform gyrus.Conclusions:PA patients with improved vision exhibit increased neural activity within the visual cortex,but decreased neural activity in subareas of the multisensory and multimodal systems beyond the vision cortex.